Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13044046 | 0.77 | MAPT (0.53) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL22790158 | 0.76 | KHK (0.46) | LMNAMEN1KMT2AJAK2JAK1 | |
| SCHEMBL7593340 | 0.76 | MAPT (0.46) | PRKDCLMNAMAPTGAAALDH1A1 | |
| SCHEMBL18029112 | 0.75 | PTGS2 (0.50) | PRKDCLMNAKMOMAPTGAA | |
| SCHEMBL7591435 | 0.74 | MAPT (0.49) | PRKDCLMNAMAPTGAAMEN1 | |
| SCHEMBL13043185 | 0.73 | RAB9A (0.55) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL7525730 | 0.73 | KMT2A (0.44) | LMNAKMOMAPTMEN1KMT2A | |
| SCHEMBL4002802 | 0.73 | SERPINE1 (0.47) | LMNAALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL7522675 | 0.73 | ALDH1A1 (0.44) | LMNAMEN1KMT2AALDH1A1POLB | |
| SCHEMBL20119973 | 0.72 | LMNA (0.43) | PRKDCLMNAKMOMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |