Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.55 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.53 |
| ▸ | EDNRA | P25101 | 2/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24429666 | 0.85 | PTGES2 (0.49) | CCR2PTGES2EDNRASLC22A12EDNRB | |
| SCHEMBL31144524 | 0.82 | TSHR (0.56) | CCR2PTGES2EDNRASLC22A12EDNRB | |
| SCHEMBL30737723 | 0.76 | PTGES2 (0.56) | CCR2PTGES2EDNRASLC22A12ALDH1A1 | |
| SCHEMBL7590368 | 0.76 | ACLY (0.58) | SLC22A12ALDH1A1LMNATSHRACLY | |
| SCHEMBL7163015 | 0.74 | ALDH1A1 (0.68) | EDNRAKAT6AALDH1A1KDM4EAURKA | |
| SCHEMBL3980189 | 0.73 | PTK2B (0.47) | CCR2PTGES2KAT6AALDH1A1LMNA | |
| SCHEMBL1028459 | 0.73 | KAT6A (0.53) | EDNRASLC22A12EDNRBKAT6AALDH1A1 | |
| SCHEMBL15555632 | 0.72 | PIK3CA (0.56) | PTGES2SLC22A12TSHR | |
| SCHEMBL30902213 | 0.72 | PIK3CA (0.56) | PTGES2SLC22A12TSHR | |
| SCHEMBL3022491 | 0.72 | PTGES2 (0.52) | CCR2PTGES2EDNRASLC22A12EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |