Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 12/20 | 0.55 |
| ▸ | CTSS | P25774 | 15/20 | 0.54 |
| ▸ | CTSL | P07711 | 14/20 | 0.54 |
| ▸ | CTSV | O60911 | 8/20 | 0.54 |
| ▸ | CTSK | P43235 | 6/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666329 | 0.78 | CTSL (0.64) | CTSBCTSSCTSLCTSVCTSK | |
| SCHEMBL7666326 | 0.78 | CTSL (0.64) | CTSBCTSSCTSLCTSVCTSK | |
| SCHEMBL9365904 | 0.78 | MAOA (0.66) | — | |
| SCHEMBL13483218 | 0.77 | CNR1 (0.57) | CTSBCTSSCTSLCTSVCTSK | |
| SCHEMBL5422983 | 0.76 | FOLH1 (0.45) | CTSBCTSSCTSLCTSVCTSK | |
| SCHEMBL5414780 | 0.75 | CTSS (0.46) | CTSBCTSSCTSLCTSVCTSK | |
| SCHEMBL23279751 | 0.75 | ACE (0.58) | CTSBCTSSCTSLCTSVCTSK | |
| SCHEMBL3174522 | 0.74 | GAA (0.60) | CTSBCTSSCTSLCTSVCTSK | |
| SCHEMBL7666762 | 0.73 | CTSL (0.48) | CTSBCTSSCTSLCTSVCTSK | |
| SCHEMBL5524114 | 0.72 | CTSL (0.56) | CTSBCTSSCTSLCTSVCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492362-B1 | Compounds and compositions as cathepsin S inhibitors | AXYS PHARMACEUTICALS, INC. | 2002-12-10 | — | — | US | disclosed |
| EP-1212302-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019796-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |