Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854758 | 0.89 | ALDH1A1 (0.45) | KMT2ATP53MEN1MAPT | |
| SCHEMBL7851726 | 0.83 | KDM4E (0.43) | KMT2ATP53MEN1 | |
| SCHEMBL7849577 | 0.82 | EDNRB (0.46) | KMT2ATP53MEN1 | |
| SCHEMBL7851104 | 0.81 | ADORA2B (0.40) | KMT2ATP53MEN1 | |
| SCHEMBL7850919 | 0.80 | ADORA2B (0.41) | KMT2ATP53MEN1MAPT | |
| SCHEMBL7854155 | 0.79 | ADORA2B (0.42) | KMT2ATP53MEN1MAPT | |
| SCHEMBL7850957 | 0.79 | ADORA2B (0.43) | KMT2ATP53MEN1 | |
| SCHEMBL7594071 | 0.79 | ADORA2B (0.54) | KMT2A | |
| SCHEMBL7851987 | 0.79 | ADORA2B (0.40) | KMT2ATP53MEN1MAPT | |
| SCHEMBL9285437 | 0.78 | ADORA2B (0.41) | KMT2ATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846119-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE AS ENDOTHELIN ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |