Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.61 |
| ▸ | RAB9A | P51151 | 7/20 | 0.61 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.54 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358033 | 0.82 | MAPT (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL13610474 | 0.82 | RAB9A (0.60) | NPC1RAB9AUBE2TASIC3SMN1; SMN2 | |
| SCHEMBL226465 | 0.82 | UBE2T (0.70) | NPC1RAB9AUBE2TASIC3SMN1; SMN2 | |
| Bromide SCHEMBL7601035 | 0.80 | UBE2T (0.68) | NPC1RAB9AUBE2TASIC3SMN1; SMN2 | |
| SCHEMBL8357496 | 0.79 | DRD2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| Fluoride SCHEMBL7600822 | 0.78 | UBE2T (0.66) | NPC1RAB9AUBE2TASIC3SMN1; SMN2 | |
| SCHEMBL1127709 | 0.75 | UBE2T (0.61) | NPC1RAB9AUBE2TASIC3SMN1; SMN2 | |
| SCHEMBL7600826 | 0.75 | UBE2T (0.61) | NPC1RAB9AUBE2TASIC3SMN1; SMN2 | |
| SCHEMBL19372016 | 0.74 | UBE2T (0.70) | NPC1RAB9AUBE2TASIC3SMN1; SMN2 | |
| SCHEMBL23965797 | 0.73 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747448-B1 | Rigidized monomethine cyanine dyes | UNIV CARNEGIE MELLON (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6207464-B1 | INCUBATING TARGET WITH DYE TO FORM A COVALENT BOND; BLUE FLUORESCING DYES | CARNEGIE MELLON UNIVERSITY | 2001-03-27 | — | — | US | disclosed |
| US-5852191-A | Rigidized monomethine cyanines | CARNEGIE MELLON UNIVERSITY (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0747448-A2 | Rigidized monomethine cyanine dyes | CARNEGIE-MELLON UNIVERSITY (US) | 1996-12-11 | — | — | EP | disclosed |