Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595142 | 1.00 | TRPM8 (0.41) | TRPM8ALOX5CNR1CNR2MTOR | |
| SCHEMBL28032819 | 0.95 | CNR1 (0.42) | TRPM8CNR1CNR2NPY1R | |
| SCHEMBL7598351 | 0.95 | CNR1 (0.42) | TRPM8CNR1CNR2NPY1R | |
| SCHEMBL7596200 | 0.95 | TRPM8 (0.37) | TRPM8ALOX5CNR1CNR2NPY1R | |
| SCHEMBL1382274 | 0.95 | CNR1 (0.42) | TRPM8CNR1CNR2NPY1R | |
| SCHEMBL7597379 | 0.94 | CNR1 (0.43) | TRPM8ALOX5CNR1CNR2 | |
| SCHEMBL7597777 | 0.94 | CNR1 (0.43) | TRPM8ALOX5CNR1CNR2 | |
| SCHEMBL7597372 | 0.93 | F2 (0.40) | TRPM8ALOX5CNR1CNR2 | |
| SCHEMBL7595822 | 0.92 | CNR1 (0.47) | TRPM8ALOX5CNR1CNR2 | |
| SCHEMBL7600642 | 0.92 | ITGB3 (0.36) | TRPM8CNR1CNR2NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | claimed |
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | claimed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | claimed |
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | disclosed |
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | disclosed |