Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596778 | 0.99 | SPHK2 (0.36) | SPHK2KMT2ABRD4TERTMAOB | |
| SCHEMBL13596779 | 0.89 | SPHK2 (0.35) | SPHK2KMT2ABRD4TERTMAOB | |
| Bromide SCHEMBL8908921 | 0.88 | KMT2A (0.34) | KMT2ABRD4MEN1ACHEMAPT | |
| Bromide SCHEMBL8909862 | 0.86 | KMT2A (0.37) | KMT2ABRD4ACHEMAPTSMN1; SMN2 | |
| SCHEMBL13596780 | 0.83 | KDM4E (0.42) | SPHK2KMT2ABRD4MEN1ACHE | |
| SCHEMBL17898189 | 0.81 | PPARA (0.45) | TSHRACHEMAPTTP53KDM4E | |
| Bromide SCHEMBL8908965 | 0.81 | TTR (0.37) | KMT2AACHEMAPTSMN1; SMN2TP53 | |
| SCHEMBL12907529 | 0.80 | TTR (0.38) | KMT2AACHEMAPTSMN1; SMN2TP53 | |
| SCHEMBL12907508 | 0.76 | GAA (0.37) | KMT2AMEN1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6254465 | 0.75 | L3MBTL1 (0.42) | KMT2AMEN1ACHEMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361817-B1 | Nucleophilic polysubstituted aryl acridinium esters, conjugates, production and uses thereof | BAYER AG (US) | 2002-08-28 | — | — | EP | disclosed |
| US-6080591-A | USEFUL IN BIOLOGICAL ASSAYS FOR DETERMINATION OF VITAMIN B12, FOLATE, CORTISOL, ESTRADIOL, AND THROMBOXANE B2 | BAYER CORPORATION (US) | 2000-06-27 | — | — | US | disclosed |
| US-5663074-A | INCUBATION OF FOLATE WITH AMINE REACTIVE COMPOUND, ACTIVATION AND INCUBATION THE ACRIDINIUM ESTER-FOLATE CONJUGATE | CHIRON DIAGNOSTICS CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5538901-A | ANALYSIS | CIBA CORNING DIAGNOSTICS CORP. (US) | 1996-07-23 | — | — | US | disclosed |
| EP-0661270-A1 | Nucleophilic polysubstituted aryl acridinium esters, conjugates, production and uses thereof | Ciba Corning Diagnostics Corp. (US) | 1995-07-05 | — | — | EP | disclosed |
| US-5241070-A | Biological analysis | CIBA CORNING DIAGNOSTICS CORP. (US) | 1993-08-31 | — | — | US | disclosed |