Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8908921 | 0.88 | KMT2A (0.34) | KMT2AACHEBRD4MAPTSMN1; SMN2 | |
| Bromide SCHEMBL7596648 | 0.86 | SPHK2 (0.36) | KMT2AACHEBRD4MAPTSMN1; SMN2 | |
| SCHEMBL13596778 | 0.85 | SPHK2 (0.36) | KMT2AACHEBRD4MAPTSMN1; SMN2 | |
| Bromide SCHEMBL8908965 | 0.78 | TTR (0.37) | KMT2AACHENPC1RAB9ARECQL | |
| SCHEMBL17898189 | 0.78 | PPARA (0.45) | ACHEMAPTTP53HPGDLMNA | |
| SCHEMBL12907529 | 0.77 | TTR (0.38) | KMT2AACHENPC1RAB9ARECQL | |
| SCHEMBL13596779 | 0.75 | SPHK2 (0.35) | KMT2ABRD4NPC1RAB9AMAPT | |
| SCHEMBL13979959 | 0.74 | SRC (0.32) | MAPTTP53POLBLMNA | |
| SCHEMBL6254465 | 0.72 | L3MBTL1 (0.42) | KMT2AACHEMAPTSMN1; SMN2TP53 | |
| Bromide SCHEMBL4190244 | 0.72 | GAA (0.36) | KMT2AACHERECQLMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656500-A | LIPOSOMES COUPLED TO MOLECULES WITH BIOLOGICAL ACTIVITY SELECTED FROM ANTIGENS, ANTIBODIES, AND NUCLEIC ACIDS, THESE CONJUGATE ENCAPSULATE HYDROPHILIC POLYSUBSTITUTED ARYL ACRIDINIUM ESTERS | CHIRON DIAGNOSTICS CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| US-5595875-A | DNA, RNA, IMMUNOASSAY, CHEMILUMINESCENCE | CIBA CORNING DIAGNOSTICS CORP. (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0353971-B1 | Acridinium esters and method for detection of an analyte using acridinium esters and liposomes | CIBA CORNING DIAGNOSTICS CORP (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5449556-A | Chemiluminescent markers | CIBA CORNING DIAGNOSTICS CORP. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5227489-A | Hydrophilic chemiluminescent markers | CIBA CORNING DIAGNOSTICS CORP. (US) | 1993-07-13 | — | — | US | disclosed |
| EP-0353971-A2 | Acridinium esters and method for detection of an analyte using acridinium esters and liposomes | Ciba Corning Diagnostics Corp. (US) | 1990-02-07 | — | — | EP | disclosed |