Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776247 | 0.88 | MTTP (0.51) | HTR1AHTR3AKMT2AALDH1A1HPGD | |
| SCHEMBL7601003 | 0.86 | HTR1A (0.51) | HTR1AHTR3ADRD3DRD2HTR2A | |
| SCHEMBL7597136 | 0.86 | NPC1 (0.40) | HTR1AHTR3AALDH1A1HPGDDRD3 | |
| SCHEMBL7597277 | 0.85 | HTR1A (0.49) | HTR1AHTR3ADRD3DRD2HTR2A | |
| SCHEMBL7600344 | 0.85 | HTR3A (0.42) | HTR1AHTR3ADRD3DRD2HTR2A | |
| SCHEMBL7593152 | 0.85 | HTR1A (0.42) | HTR1AHTR3ADRD3DRD2MCHR1 | |
| SCHEMBL7720309 | 0.85 | DRD3 (0.51) | HTR1ADRD3DRD2HTR2ACHRM2 | |
| SCHEMBL7599958 | 0.84 | DRD3 (0.43) | HTR1ADRD3DRD2MCHR1CHRM2 | |
| SCHEMBL7596491 | 0.84 | HTR1A (0.48) | HTR1AHTR3ADRD3DRD2HTR2A | |
| SCHEMBL7596831 | 0.83 | HTR1A (0.42) | HTR1ADRD3DRD2HTR2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |