Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 12/20 | 0.40 |
| ▸ | DRD2 | P14416 | 8/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 4/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | MTTP | P55157 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598203 | 0.92 | HTR1A (0.47) | HTR1ADRD3DRD2HTR3AFAAH | |
| SCHEMBL7601003 | 0.89 | HTR1A (0.51) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7598268 | 0.89 | HTR3A (0.39) | HTR1ADRD3DRD2HTR3AFAAH | |
| SCHEMBL7595519 | 0.88 | DRD3 (0.39) | HTR1ADRD3DRD2HTR3AFAAH | |
| SCHEMBL6769810 | 0.88 | HTR1A (0.50) | HTR1ADRD3CHRM2ADRA2AADORA3 | |
| SCHEMBL7594432 | 0.87 | HTR1A (0.47) | HTR1ADRD3DRD2HTR3AFAAH | |
| SCHEMBL7596831 | 0.87 | HTR1A (0.42) | HTR1ADRD3DRD2HTR2ACHRM2 | |
| SCHEMBL7600219 | 0.86 | HTR1A (0.41) | HTR1ADRD3DRD2HTR3ACHRM2 | |
| SCHEMBL7596491 | 0.86 | HTR1A (0.48) | HTR1ADRD3DRD2HTR3AHTR2A | |
| SCHEMBL7596715 | 0.85 | HTR1A (0.43) | HTR1ADRD3DRD2HTR3AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |