Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PLEC | Q15149 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593014 | 0.84 | MAPT (0.47) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7593456 | 0.80 | HCAR3 (0.50) | NEU3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7594615 | 0.78 | GRM1 (0.56) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3891611 | 0.78 | NPC1 (0.64) | NEU3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL2344997 | 0.77 | GAA (0.63) | NEU3MEN1KMT2AALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL8374327 | 0.76 | GAA (0.61) | NEU3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL28803059 | 0.75 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL28803057 | 0.75 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| 3-Hydroxy-4-Acetylaminobenzoic Acid SCHEMBL8018270 | 0.75 | MAPT (0.65) | NEU3MEN1KMT2AALDH1A1HPGD | |
| 3-Hydroxy-4-Acetylaminobenzoic Acid SCHEMBL31026207 | 0.75 | MAPT (0.65) | NEU3MEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020082280-A1 | Method of inhibiting neoplastic cells with benzimidazole derivatives | OSI PHARMACEUTICALS, INC. | 2002-06-27 | — | — | US | disclosed |
| US-6369092-B1 | Method for treating neoplasia by exposure to substituted benzimidazole derivatives | CELL PATHWAYS, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6348032-B1 | POTENT COMPOUNDS THAT INDUCE APOPTOSIS IN NEOPLASTIC CELLS (BUT NOT SUBSTANTIALLY IN NORMAL CELLS), WITHOUT SUBSTANTIALLY INHIBITING PGE-2. | CELL PATHWAYS, INC. | 2002-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082280-A1 | Method of inhibiting neoplastic cells with benzimidazole derivatives | MKI67, CCNI, TMBIM6 | NEU3 1734/4885MEN1 1677/4885KMT2A 1590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.