SCHEMBL7597707

SCHEMBL7597707

CC(C)SC(=N)Nc1ccc(CCN(C)Cc2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BCHE P06276 3/20 0.46
ACHE P22303 3/20 0.46
SIGMAR1 Q99720 3/20 0.43
TMEM97 Q5BJF2 2/20 0.43
HDAC1 Q13547 1/20 0.42
NAMPT P43490 1/20 0.42
LTA4H P09960 2/20 0.42
NPY5R Q15761 1/20 0.40
CARM1 Q86X55 1/20 0.39
PRMT6 Q96LA8 1/20 0.39
PRMT8 Q9NR22 1/20 0.39
RORC P51449 1/20 0.39
MAOA P21397 1/20 0.39
MAOB P27338 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7595886 0.84 ACHE (0.47) BCHEACHESIGMAR1TMEM97HDAC1
SCHEMBL7598493 0.81 BCHE (0.51) BCHEACHESIGMAR1TMEM97HDAC1
SCHEMBL6960940 0.78 ACHE (0.48) BCHEACHESIGMAR1TMEM97HDAC1
SCHEMBL21485029 0.76 ACHE (0.51) BCHEACHESIGMAR1TMEM97HDAC1
SCHEMBL7600769 0.76 ACHE (0.51) BCHEACHESIGMAR1TMEM97HDAC1
SCHEMBL6958297 0.74 BCHE (0.44) BCHEACHESIGMAR1TMEM97HDAC1
SCHEMBL8402960 0.73 SIGMAR1 (0.71) SIGMAR1CARM1PRMT6PRMT8MAOA
SCHEMBL16980535 0.71 SIGMAR1 (0.56) SIGMAR1CARM1PRMT6PRMT8MEN1
SCHEMBL12018644 0.71 SIGMAR1 (0.59) BCHEACHESIGMAR1HDAC1CARM1
SCHEMBL4422628 0.71 SIGMAR1 (0.59) BCHESIGMAR1TMEM97HDAC1CARM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0782567-B2 ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS ASTRA AB (SE) 2002-12-11 EP claimed
EP-0782567-B1 ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS ASTRA AB (SE) 1999-06-30 EP claimed
US-5721247-A Isothiourea derivatives useful in therapy ASTRA AKTIEBOLAG (SE) 1998-02-24 US claimed
EP-0782567-A1 ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS Astra Aktiebolag (SE) 1997-07-09 EP claimed
WO-1996009286-A1 ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS ASTRA AKTIEBOLAG (SE) 1996-03-28 WO claimed
EP-0782567-B2 ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS ASTRA AB (SE) 2002-12-11 EP disclosed
EP-0782567-B1 ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS ASTRA AB (SE) 1999-06-30 EP disclosed
US-5721247-A Isothiourea derivatives useful in therapy ASTRA AKTIEBOLAG (SE) 1998-02-24 US disclosed
EP-0782567-A1 ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS Astra Aktiebolag (SE) 1997-07-09 EP disclosed
WO-1996009286-A1 ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS ASTRA AKTIEBOLAG (SE) 1996-03-28 WO disclosed