Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21485029 | 0.86 | ACHE (0.51) | ACHEBCHESIGMAR1CARM1PRMT6 | |
| SCHEMBL17545651 | 0.84 | BCHE (0.49) | ACHEBCHEALDH1A1TP53TYR | |
| SCHEMBL7597734 | 0.81 | POLB (0.59) | ACHEALDH1A1MAPTHDAC1 | |
| SCHEMBL7598493 | 0.81 | BCHE (0.51) | ACHEBCHESIGMAR1CARM1PRMT6 | |
| SCHEMBL6680641 | 0.81 | HRH3 (0.65) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL8402960 | 0.78 | SIGMAR1 (0.71) | ALDH1A1TSHRSIGMAR1CARM1PRMT6 | |
| SCHEMBL6960940 | 0.77 | ACHE (0.48) | ACHEBCHESIGMAR1CARM1PRMT6 | |
| SCHEMBL6681291 | 0.77 | ALDH1A1 (0.51) | ACHEBCHEALDH1A1TP53TYR | |
| SCHEMBL7595886 | 0.76 | ACHE (0.47) | ACHEBCHESIGMAR1CARM1PRMT6 | |
| SCHEMBL12018644 | 0.76 | SIGMAR1 (0.59) | ACHEBCHESIGMAR1CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11564911-B2 | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing | DUKE UNIVERSITY (US) | 2023-01-31 | — | — | US | disclosed |
| US-11229628-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2022-01-25 | — | — | US | disclosed |
| US-11014896-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2021-05-25 | — | — | US | disclosed |
| US-20190315700-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2019-10-17 | — | — | US | disclosed |
| US-10329265-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20190091206-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | DUKE UNIVERSITY | 2019-03-28 | — | — | US | disclosed |
| WO-2017177200-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | DUKE UNIVERSITY (US) | 2017-10-12 | — | — | WO | disclosed |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2017-09-21 | — | — | US | disclosed |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2017-09-21 | — | — | US | disclosed |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| WO-2016028325-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY (US) | 2016-02-25 | — | — | WO | disclosed |
| EP-0782567-B2 | ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS | ASTRA AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| EP-0782567-B1 | ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS | ASTRA AB (SE) | 1999-06-30 | — | — | EP | disclosed |
| US-5721247-A | Isothiourea derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1998-02-24 | — | — | US | disclosed |
| EP-0782567-A1 | ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS | Astra Aktiebolag (SE) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009286-A1 | ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS | ASTRA AKTIEBOLAG (SE) | 1996-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315700-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | ACHE 1004/4885BCHE 3185/4885ALDH1A1 2640/4885 |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | ACHE 1004/4885BCHE 3185/4885ALDH1A1 2640/4885 |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | ACHE 1004/4885BCHE 3185/4885ALDH1A1 2640/4885 |
| US-11229628-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | ACHE 1004/4885BCHE 3185/4885ALDH1A1 2640/4885 |
| US-11564911-B2 | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing | TRPA1, TRPV4, TRPV1 | ACHE 498/4885BCHE 2668/4885ALDH1A1 1975/4885 |
| US-10329265-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | ACHE 1004/4885BCHE 3185/4885ALDH1A1 2640/4885 |
| US-20190091206-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | TRPA1, TRPV4, TRPV1 | ACHE 498/4885BCHE 2668/4885ALDH1A1 1975/4885 |
| US-11014896-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | ACHE 1004/4885BCHE 3185/4885ALDH1A1 2640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.