Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28830240 | 0.85 | LMNA (0.65) | LMNACES2CES1CYP2D6TDP1 | |
| SCHEMBL7827857 | 0.83 | CYP2D6 (0.74) | LMNACES2CES1CYP2D6TDP1 | |
| SCHEMBL28017300 | 0.83 | CYP2D6 (0.73) | LMNACES2CES1CYP2D6TDP1 | |
| SCHEMBL726677 | 0.80 | KMO (0.48) | CYP2D6TSHRKMT2A | |
| SCHEMBL19984715 | 0.80 | LMNA (0.59) | LMNACES2CES1CYP2D6TDP1 | |
| SCHEMBL19984712 | 0.80 | LMNA (0.59) | LMNACES2CES1CYP2D6TDP1 | |
| SCHEMBL29719387 | 0.79 | TDP1 (0.59) | LMNACES2CES1CYP2D6TDP1 | |
| SCHEMBL4255324 | 0.78 | CYP2D6 (0.54) | LMNACES2CES1CYP2D6TDP1 | |
| SCHEMBL4255321 | 0.78 | CYP2D6 (0.54) | LMNACES2CES1CYP2D6TDP1 | |
| SCHEMBL27484428 | 0.78 | LMNA (0.58) | LMNACES2CES1CYP2D6TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020087013-A1 | Methods for preparing new taxoids and pharmaceutical compositions containing them | AVENTIS PHARMA S.A. | 2002-07-04 | — | — | US | claimed |
| US-20020010348-A1 | Methods for preparing new taxoids and pharmaceutical compositions containing them | AVENTIS PHARMA S.A. (FR) | 2002-01-24 | — | — | US | claimed |
| US-6232477-B1 | SILYLATING A BACCATIN; ACETYLATION; DEBLOCKING | AVENTIS PHARMA S.A. (FR) | 2001-05-15 | — | — | US | claimed |
| US-20020087013-A1 | Methods for preparing new taxoids and pharmaceutical compositions containing them | AVENTIS PHARMA S.A. | 2002-07-04 | — | — | US | disclosed |
| US-20020010348-A1 | Methods for preparing new taxoids and pharmaceutical compositions containing them | AVENTIS PHARMA S.A. (FR) | 2002-01-24 | — | — | US | disclosed |
| US-6232477-B1 | SILYLATING A BACCATIN; ACETYLATION; DEBLOCKING | AVENTIS PHARMA S.A. (FR) | 2001-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010348-A1 | Methods for preparing new taxoids and pharmaceutical compositions containing them | TOP1, TMSB4X, TUBB1 | LMNA 296/4885CES2 1791/4885CES1 1195/4885 |
| US-20020087013-A1 | Methods for preparing new taxoids and pharmaceutical compositions containing them | TOP1, TMSB4X, TUBB1 | LMNA 296/4885CES2 1791/4885CES1 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.