Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3842605 | 0.98 | HTR1A (0.57) | HTR1ASIGMAR1SLC6A4SLC6A3 | |
| SCHEMBL12806776 | 0.92 | SIGMAR1 (0.57) | HTR1ASIGMAR1 | |
| SCHEMBL12806750 | 0.90 | SIGMAR1 (0.55) | HTR1ASIGMAR1 | |
| SCHEMBL2722580 | 0.84 | HTR1A (0.63) | HTR1ASIGMAR1SLC6A4SLC6A3GRIN2D | |
| SCHEMBL5863917 | 0.84 | SIGMAR1 (0.61) | SIGMAR1SLC6A4 | |
| SCHEMBL14035242 | 0.83 | GAA (0.65) | SIGMAR1 | |
| SCHEMBL7547846 | 0.83 | HTR1A (0.61) | HTR1ASLC6A4SLC6A3 | |
| SCHEMBL2797036 | 0.83 | GAA (0.65) | SIGMAR1 | |
| SCHEMBL28753859 | 0.83 | HTR1A (0.61) | HTR1ASLC6A4SLC6A3 | |
| SCHEMBL14035360 | 0.83 | GAA (0.65) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167121-B1 | SUBSTITUTED PHENYLPIPERAZINYL PROPANOLS, PROCESS FOR THEIR PREPARATION, THEIR USE, AND COMPOSITIONS CONTAINING THESE COMPOUNDS | Beiersdorf Aktiengesellschaft (DE) | 1991-10-23 | — | — | EP | claimed |
| US-4631281-A | ANTICOAGULANTS, ASTHMA, HYPOTENSIVE AGENTS, BRONCHOPILATORS, INOTROPIC AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1986-12-23 | — | — | US | claimed |
| EP-0167121-A2 | Substituted phenylpiperazinyl propanols, process for their preparation, their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | claimed |
| EP-0891344-B1 | ALPHA-1 ADRENERGIC RECEPTOR ANTAGONISTS | SOD CONSEILS RECH APPLIC (FR) | 2002-12-18 | — | — | EP | disclosed |
| US-6395739-B1 | CARDIOVASCUALR DISORDERS; HYPOTENSIVE AGENTS | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-28 | — | — | US | disclosed |
| US-6300499-B1 | α1-adrenergic receptor antagonists | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-1090913-A1 | N-PHENYL-N'-PHENYLPROPYLPIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Zeria Pharmaceutical Co., Ltd. (JP) | 2001-04-11 | — | — | EP | disclosed |
| EP-0891344-A1 | ALPHA 1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997037983-A1 | α1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1997-10-16 | — | — | WO | disclosed |
| EP-0167121-B1 | SUBSTITUTED PHENYLPIPERAZINYL PROPANOLS, PROCESS FOR THEIR PREPARATION, THEIR USE, AND COMPOSITIONS CONTAINING THESE COMPOUNDS | Beiersdorf Aktiengesellschaft (DE) | 1991-10-23 | — | — | EP | disclosed |
| EP-0167121-B1 | SUBSTITUTED PHENYLPIPERAZINYL PROPANOLS, PROCESS FOR THEIR PREPARATION, THEIR USE, AND COMPOSITIONS CONTAINING THESE COMPOUNDS | Beiersdorf Aktiengesellschaft (DE) | 1991-10-23 | — | — | EP | disclosed |
| EP-0056866-B1 | PHENYLPIPERAZINE DERIVATIVES OF HETERYLPHENOLS AND HETARYLANILINES, THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS | BASF Aktiengesellschaft (DE) | 1985-06-19 | — | — | EP | disclosed |
| EP-0034276-B1 | PHENYLPIPERAZINE DERIVATIVES OF 1,3,4-OXADIAZOLYL PHENOLS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1983-11-09 | — | — | EP | disclosed |
| US-4353904-A | TREATMENT OF HYPERTONIA | BASF AKTIENGESELLSCHAFT (DE) | 1982-10-12 | — | — | US | disclosed |
| US-4353904-A | TREATMENT OF HYPERTONIA | BASF AKTIENGESELLSCHAFT (DE) | 1982-10-12 | — | — | US | disclosed |
| EP-0056866-A2 | Phenylpiperazine derivatives of heterylphenols and hetarylanilines, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1982-08-04 | — | — | EP | disclosed |
| EP-0056486-A2 | Phenylpiperazinyl-propanoles of hetarylphenols, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1982-07-28 | — | — | EP | disclosed |
| EP-0056486-A2 | Phenylpiperazinyl-propanoles of hetarylphenols, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1982-07-28 | — | — | EP | disclosed |
| EP-0056486-A2 | Phenylpiperazinyl-propanoles of hetarylphenols, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1982-07-28 | — | — | EP | disclosed |
| EP-0034276-A2 | Phenylpiperazine derivatives of 1,3,4-oxadiazolyl phenols, their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1981-08-26 | — | — | EP | disclosed |