SCHEMBL7598754

SCHEMBL7598754

CN(Cc1ccc(S(C)(=O)=O)c(S(=O)(=O)NC(C)(C)C)c1)S(C)(=O)=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.35
KDM4E B2RXH2 2/20 0.35
MAPT P10636 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
HPGD P15428 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
ALDH1A1 P00352 7/20 0.34
POLB P06746 1/20 0.34
CYP1A2 P05177 1/20 0.34
HSD17B10 Q99714 1/20 0.34
GRIA2 P42262 1/20 0.33
NSD2 O96028 2/20 0.33
BRD4 O60885 1/20 0.32
BRD2 P25440 1/20 0.32
BRD3 Q15059 1/20 0.32
PARG Q86W56 2/20 0.32
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7596576 0.82 LMNA (0.38) LMNAKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL7600121 0.80 CA2 (0.40) KDM4ESMN1; SMN2ALDH1A1CYP1A2HSD17B10
SCHEMBL7600872 0.78 SMN1; SMN2 (0.37) LMNAKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL7600544 0.72 ALDH1A1 (0.46) LMNAKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL7599518 0.71 GAA (0.51) MAPTCYP1A2
SCHEMBL13075810 0.68 NSD2 (0.51) LMNAKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL12169353 0.67 KCNH2 (0.43) LMNAALDH1A1GRIA2
SCHEMBL8257948 0.67 HTT (0.40) LMNAKDM4EMAPTSMN1; SMN2MEN1
SCHEMBL21962959 0.67 ALDH1A1 (0.42) KDM4EMAPTSMN1; SMN2HPGDRAB9A
SCHEMBL21962901 0.67 KMT2A (0.39) LMNAKDM4EMAPTSMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0900023-B1 SUBSTITUTED AMINOMETHYL PHENYL SULPHONYL UREAS, THEIR PRODUCTION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS BAYER CROPSCIENCE GMBH (DE) 2002-11-27 EP disclosed
US-5925596-A PRE-EMERGENCE AND POST-EMERGENCE HERBICIDES HOECHST-SCHERING AGREVO GMBH (DE) 1999-07-20 US disclosed
EP-0900023-A1 SUBSTITUTED AMINOMETHYL PHENYL SULPHONYL UREAS, THEIR PRODUCTION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1999-03-10 EP disclosed
WO-1997040690-A1 SUBSTITUTED AMINOMETHYL PHENYL SULPHONYL UREAS, THEIR PRODUCTION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS HOECHST SCHERING AGREVO GMBH (DE) 1997-11-06 WO disclosed