Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7596315 | 1.00 | MEN1 (0.42) | MEN1KMT2AALOX5TRPM8CNR1 | |
| SCHEMBL7600674 | 0.93 | TRPM8 (0.46) | MEN1KMT2AALOX5TRPM8HTR2A | |
| Hydrochloric Acid SCHEMBL7594995 | 0.92 | TRPM8 (0.45) | MEN1KMT2AALOX5TRPM8HTR2A | |
| SCHEMBL7596331 | 0.90 | TRPM8 (0.41) | ALOX5TRPM8CNR1CNR2HTR2A | |
| Hydrochloric Acid SCHEMBL7600878 | 0.89 | TRPM8 (0.41) | ALOX5TRPM8CNR1CNR2HTR2A | |
| Hydrochloric Acid SCHEMBL7600663 | 0.89 | TRPM8 (0.41) | ALOX5TRPM8HTR2AHRH1ALDH1A1 | |
| SCHEMBL7597931 | 0.87 | ALDH1A1 (0.44) | KMT2AALOX5TRPM8CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL7600447 | 0.87 | ALOX5 (0.42) | ALOX5TRPM8ALDH1A1 | |
| SCHEMBL7595296 | 0.87 | ALDH1A1 (0.44) | KMT2AALOX5TRPM8CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL7600168 | 0.86 | ALDH1A1 (0.46) | KMT2AALOX5TRPM8CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017672-B1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | disclosed |
| EP-1017672-A1 | NEW NPY ANTAGONISTS | AstraZeneca AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015498-A1 | NEW NPY ANTAGONISTS | ASTRAZENECA AB (SE) | 1999-04-01 | — | — | WO | disclosed |