SCHEMBL7600529

SCHEMBL7600529

OP(Cl)Oc1ccccc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TSHR P16473 1/20 0.39
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
PKM P14618 1/20 0.38
CXCL8 P10145 1/20 0.38
XIAP P98170 1/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 2/20 0.36
DPP4 P27487 1/20 0.36
HTT P42858 3/20 0.36
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36
TP53 P04637 1/20 0.36
SLC6A4 P31645 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A3 Q01959 1/20 0.35
USP2 O75604 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6974 0.85 CA1 (0.35) LMNASMN1; SMN2TSHRKMT2AALDH1A1
SCHEMBL1364726 0.84 LMNA (0.42) LMNASMN1; SMN2TSHRMEN1KMT2A
SCHEMBL5503600 0.84 LMNA (0.42) LMNASMN1; SMN2TSHRMEN1KMT2A
SCHEMBL7602939 0.81 LMNA (0.43) LMNASMN1; SMN2TSHRMEN1KMT2A
SCHEMBL339290 0.79 CA1 (0.31) TSHRTP53
SCHEMBL5503597 0.78 LMNA (0.45) LMNASMN1; SMN2TSHRMEN1KMT2A
SCHEMBL10937183 0.77 CA2 (0.48) LMNASMN1; SMN2TSHRKMT2AALDH1A1
SCHEMBL11553081 0.76 LMNA (0.43) LMNASMN1; SMN2TSHRMEN1KMT2A
SCHEMBL11677163 0.76 LMNA (0.43) LMNASMN1; SMN2TSHRMEN1KMT2A
SCHEMBL27594718 0.76 SMN1; SMN2 (0.41) LMNASMN1; SMN2TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0135587-B2 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS SYNGENE INC (US) 2002-12-18 EP disclosed
US-5817786-A Single-stranded labelled oligonucleotides of preselected sequences MOLECULAR BIOSYSTEMS, INC. (US) 1998-10-06 US disclosed
US-5668266-A Synthesis of single-stranded labelled oligonucleotides of preselected sequence SYNGENE, INC. (US) 1997-09-16 US disclosed
US-5541313-A Single-stranded labelled oligonucleotides of preselected sequence MOLECULAR BIOSYSTEMS, INC. (US) 1996-07-30 US disclosed
US-4948882-A Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis SYNGENE, INC. (US) 1990-08-14 US disclosed
EP-0135587-B1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS SYNGENE, INC. (US) 1990-05-02 EP disclosed
EP-0135587-A4 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1986-04-02 EP disclosed
EP-0135587-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1985-04-03 EP disclosed
WO-1984003285-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS MOLECULAR BIOSYSTEMS INC (US) 1984-08-30 WO disclosed