SCHEMBL7602939

SCHEMBL7602939

Clc1ccccc1OP(Cl)Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TSHR P16473 3/20 0.43
ALDH1A1 P00352 2/20 0.40
HPGD P15428 2/20 0.38
SLC6A4 P31645 3/20 0.37
L3MBTL1 Q9Y468 3/20 0.37
SLC6A2 P23975 2/20 0.37
SLC6A3 Q01959 2/20 0.37
MEN1 O00255 1/20 0.36
PKM P14618 1/20 0.36
KMT2A Q03164 1/20 0.36
MAPT P10636 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HTT P42858 1/20 0.36
CXCL8 P10145 1/20 0.36
GAA P10253 1/20 0.35
RAB9A P51151 1/20 0.35
DPP4 P27487 1/20 0.34
RXRA P19793 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3369050 0.89 LMNA (0.50) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL5503597 0.82 LMNA (0.45) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL7600529 0.81 LMNA (0.41) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL11677163 0.80 LMNA (0.43) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL11553081 0.80 LMNA (0.43) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL1364726 0.78 LMNA (0.42) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL5503600 0.78 LMNA (0.42) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL7937629 0.76 LMNA (0.41) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL10938009 0.75 TSHR (0.52) LMNASMN1; SMN2TSHRALDH1A1HPGD
SCHEMBL11700624 0.75 LMNA (0.39) LMNASMN1; SMN2TSHRALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10730904-B2 Method for liquid-phase synthesis of nucleic acid TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-08-04 US disclosed
EP-2921499-B1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACIDS TAKEDA PHARMACEUTICALS CO (JP) 2020-01-22 EP disclosed
US-20190135852-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-05-09 US disclosed
US-20150315229-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-11-05 US disclosed
EP-2921499-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID Takeda Pharmaceutical Company Limited (JP) 2015-09-23 EP disclosed
EP-0135587-B2 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS SYNGENE INC (US) 2002-12-18 EP disclosed
US-6248916-B1 WATER SOLUBLE, STRAIGHT CHAIN BORON-RICH OLIGOPHOSPHATE WHICH COMPRISES AN ORDERED PLURALITY OF CARBORANE MONOMER UNITS HAVING TWO HYDROXYL GROUPS ATTACHED THERETO BEING LINKED BY THE HYDROXYL GROUPS TO PHOSPHATE UNITS REGENTS OF THE UNIVERSITY OF CALIFORNIA 2001-06-19 US disclosed
US-5856551-A REACTING DIHYDROXYCARBORANE WITH PHOSPHORUS COUPLING AGENT;THEN ALCOHOL THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-01-05 US disclosed
US-5817786-A Single-stranded labelled oligonucleotides of preselected sequences MOLECULAR BIOSYSTEMS, INC. (US) 1998-10-06 US disclosed
US-5668266-A Synthesis of single-stranded labelled oligonucleotides of preselected sequence SYNGENE, INC. (US) 1997-09-16 US disclosed
WO-1989005853-A1 NUCLEIC ACID CHELATE CONJUGATE AS THERAPEUTIC AND DIAGNOSTIC AGENTS SYNTHETIC GENETICS (US) 1989-06-29 WO disclosed
EP-0321548-A1 NOVEL AMPHIPHILIC NUCLEIC ACID CONJUGATES SYNTHETIC GENETICS (US) 1989-06-28 EP disclosed
WO-1988009810-A1 NOVEL AMPHIPHILIC NUCLEIC ACID CONJUGATES SYNTHETIC GENETICS (US) 1988-12-15 WO disclosed
EP-0135587-A4 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1986-04-02 EP disclosed
EP-0135587-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1985-04-03 EP disclosed
WO-1984003285-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS MOLECULAR BIOSYSTEMS INC (US) 1984-08-30 WO disclosed
EP-0050841-B1 FLUID BED PROCESS FOR PREPARING PHENYLPHOSPHONOUS DICHLORIDE STAUFFER CHEMICAL COMPANY (US) 1984-05-02 EP disclosed
US-4436673-A BENZENE REACTED WITH PHOSPHORUS TRICHLORIDE STAUFFER CHEMICAL COMPANY (US) 1984-03-13 US disclosed
US-4409152-A Continuous high pressure process for preparing phenylphosphonous dichloride STAUFFER CHEMICAL COMPANY (US) 1983-10-11 US disclosed
EP-0050841-A1 Fluid bed process for preparing phenylphosphonous dichloride STAUFFER CHEMICAL COMPANY (US) 1982-05-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150315229-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID POLM, POLRMT, RNMT LMNA 233/4885SMN1; SMN2 920/4885TSHR 495/4885
US-20190135852-A1 METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID RNGTT, POLR2H, POLR2E LMNA 214/4885SMN1; SMN2 950/4885TSHR 551/4885
US-10730904-B2 Method for liquid-phase synthesis of nucleic acid RNGTT, POLR2H, POLR2E LMNA 204/4885SMN1; SMN2 1165/4885TSHR 411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.