Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.81 |
| ▸ | MAPT | P10636 | 8/20 | 0.81 |
| ▸ | RAB9A | P51151 | 8/20 | 0.81 |
| ▸ | HPGD | P15428 | 8/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.81 |
| ▸ | NPC1 | O15118 | 7/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.81 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.81 |
| ▸ | RELA | Q04206 | 2/20 | 0.81 |
| ▸ | ATM | Q13315 | 1/20 | 0.81 |
| ▸ | TP53 | P04637 | 6/20 | 0.75 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.64 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.64 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.64 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 2/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1258969 | 0.93 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL9767559 | 0.93 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL11544615 | 0.92 | MAPT (0.73) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL6707325 | 0.92 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL7610004 | 0.91 | MAPT (0.81) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL12942543 | 0.86 | RAB9A (1.00) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL11367720 | 0.84 | SMN1; SMN2 (0.70) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL9608562 | 0.84 | RAB9A (0.68) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL2242268 | 0.84 | MAPT (0.70) | SMN1; SMN2MAPTRAB9AHPGDKDM4E | |
| SCHEMBL5638115 | 0.83 | MAPT (0.70) | SMN1; SMN2MAPTRAB9AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150057218-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS INC (US) | 2015-02-26 | — | — | US | disclosed |
| US-8921369-B2 | Inhibitors of HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8877707-B2 | Inhibitors of HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2014-11-04 | — | — | US | disclosed |
| US-20130203656-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130096101-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2013-04-18 | — | — | US | disclosed |
| US-20120122864-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096101-A1 | INHIBITORS OF HCV NS5A | HAVCR2, MAVS, EIF2AK2 | SMN1; SMN2 4637/4885MAPT 3230/4885RAB9A 1313/4885 |
| US-20120122864-A1 | INHIBITORS OF HCV NS5A | HAVCR2, MAVS, EIF2AK2 | SMN1; SMN2 4634/4885MAPT 3250/4885RAB9A 1482/4885 |
| US-20150057218-A1 | INHIBITORS OF HCV NS5A | HAVCR2, MAVS, EIF2AK2 | SMN1; SMN2 4634/4885MAPT 3250/4885RAB9A 1482/4885 |
| US-20130203656-A1 | INHIBITORS OF HCV NS5A | HAVCR2, MAVS, EIF2AK2 | SMN1; SMN2 4634/4885MAPT 3250/4885RAB9A 1482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.