Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 9/20 | 0.37 |
| ▸ | GPR142 | Q7Z601 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL759900 | 0.87 | FAAH (0.44) | GRIA2FFAR1FFAR4FAAHGPR142 | |
| SCHEMBL781904 | 0.87 | GRIA2 (0.40) | GRIA2FFAR1FFAR4PDE4APDE4B | |
| SCHEMBL759673 | 0.81 | MAPT (0.43) | FAAHNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL756393 | 0.76 | GPR142 (0.38) | FAAHMGLLGPR142 | |
| SCHEMBL760502 | 0.76 | FFAR1 (0.38) | FFAR1FAAHGPR142 | |
| SCHEMBL758615 | 0.76 | TDP1 (0.45) | FFAR1FAAHALDH1A1 | |
| SCHEMBL762296 | 0.76 | GRIA2 (0.55) | GRIA2FFAR1FFAR4PDE4APDE4B | |
| SCHEMBL781918 | 0.74 | FAAH (0.39) | GRIA2FFAR1FFAR4FAAHGPR142 | |
| SCHEMBL762297 | 0.74 | GRIA2 (0.45) | GRIA2FFAR1FFAR4PDE4APDE4B | |
| SCHEMBL765579 | 0.72 | LMNA (0.51) | GPR142NPC1ALDH1A1NFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431360-B1 | Derivatives of dihydrobenzoxathiazepine, method of preparing same and pharmaceutical compositions containing them as well as their uses as modulators of AMPA receptors | SERVIER LAB (FR) | 2013-04-17 | — | — | EP | disclosed |
| WO-2012035216-A1 | DIHYDROBENZOXATHIAZEPINE DERIVATIVES, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS AND USE AS AMPA RECEPTOR MODULATORS | LES LABORATOIRES SERVIER (FR) | 2012-03-22 | — | — | WO | disclosed |
| EP-2431360-A1 | Derivatives of dihydrobenzoxathiazepine, method of preparing same and pharmaceutical compositions containing them as well as their uses as modulators of AMPA receptors | Les Laboratoires Servier (FR) | 2012-03-21 | — | — | EP | disclosed |