Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 4/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914608 | 0.94 | HRH3 (0.36) | HRH3ALDH1A1SMN1; SMN2CHRNB4CHRNA3 | |
| SCHEMBL7913694 | 0.94 | HRH3 (0.36) | HRH3SLC6A4ALDH1A1SMN1; SMN2CACNA1F | |
| SCHEMBL7535010 | 0.90 | ADRA1A (0.37) | HRH3SLC6A4ALDH1A1SMN1; SMN2CACNA1F | |
| SCHEMBL7916689 | 0.89 | HRH3 (0.36) | HRH3ALDH1A1SMN1; SMN2CACNA1FCACNA1D | |
| SCHEMBL7418138 | 0.88 | SIGMAR1 (0.36) | HRH3ALDH1A1BCHEGPBAR1 | |
| SCHEMBL7916244 | 0.87 | NPC1 (0.44) | HRH3ALDH1A1SMN1; SMN2CACNA1FCACNA1D | |
| SCHEMBL7914613 | 0.86 | HTR1A (0.40) | HRH3ALDH1A1SMN1; SMN2CACNA1FCACNA1D | |
| SCHEMBL7422291 | 0.85 | HRH3 (0.34) | HRH3SLC6A4ALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL7906593 | 0.85 | HRH3 (0.34) | HRH3SLC6A4ALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL7906535 | 0.85 | ALDH1A1 (0.37) | HRH3SLC6A4ALDH1A1SMN1; SMN2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218538-B1 | ANTAGONISTS OF N-TYPE NEURONAL CALCIUM CHANNELS USEFUL IN THE TREATMENT OF CEREBROVASCULAR ISCHAEMIA AND PAIN. | ASTRA AKTIEBOLAG (SE) | 2001-04-17 | — | — | US | claimed |
| US-6218538-B1 | ANTAGONISTS OF N-TYPE NEURONAL CALCIUM CHANNELS USEFUL IN THE TREATMENT OF CEREBROVASCULAR ISCHAEMIA AND PAIN. | ASTRA AKTIEBOLAG (SE) | 2001-04-17 | — | — | US | disclosed |
| EP-0993450-A1 | NEW COMPOUNDS | Astra Aktiebolag (publ) (SE) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001438-A1 | NEW COMPOUNDS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1999-01-14 | — | — | WO | disclosed |