Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7130569 | 0.87 | HTR1A (0.34) | HTR1AKDM4EALDH1A1 | |
| SCHEMBL7128154 | 0.86 | HTR1A (0.42) | HTR1ADRD2DRD3HTR2ADRD4 | |
| SCHEMBL7128136 | 0.82 | ALDH1A1 (0.42) | HTR1AKDM4EDRD2HTR2AALDH1A1 | |
| SCHEMBL7130709 | 0.79 | L3MBTL1 (0.41) | HTR1AKDM4EDRD2DRD3DRD4 | |
| SCHEMBL7128466 | 0.79 | L3MBTL1 (0.47) | HTR1AKDM4ELMNADRD2DRD3 | |
| SCHEMBL7124375 | 0.76 | HTR1A (0.33) | HTR1ADRD2DRD3HTR2ADRD4 | |
| SCHEMBL7126591 | 0.76 | ALDH1A1 (0.34) | HTR1ADRD2DRD3HTR2ADRD4 | |
| SCHEMBL7129896 | 0.76 | HTR1A (0.35) | HTR1AKDM4ELMNADRD2DRD3 | |
| SCHEMBL3917127 | 0.76 | DRD2 (0.51) | HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL3914428 | 0.76 | DRD2 (0.51) | HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246820-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049683-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |