SCHEMBL7603763

SCHEMBL7603763

CCOC(=O)c1nc2ccc(Br)cc2s1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.52
ALDH1A1 P00352 4/20 0.52
RAB9A P51151 9/20 0.51
NPC1 O15118 7/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
DYRK1A Q13627 1/20 0.50
PPARA Q07869 2/20 0.49
STAT1 P42224 1/20 0.49
MAPT P10636 5/20 0.46
HPGD P15428 2/20 0.46
KDM4E B2RXH2 1/20 0.46
ALPL P05186 1/20 0.46
GAA P10253 1/20 0.46
SHMT2 P34897 1/20 0.45
ATM Q13315 1/20 0.45
CA2 P00918 1/20 0.44
SIRT2 Q8IXJ6 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17038164 0.86 PTPN1 (0.59) SMN1; SMN2ALDH1A1RAB9ANPC1DYRK1A
SCHEMBL17038135 0.84 SMN1; SMN2 (0.54) SMN1; SMN2ALDH1A1RAB9ANPC1CYP1A2
SCHEMBL13805533 0.84 HSD17B1 (0.55) SMN1; SMN2RAB9ANPC1CYP1A2CYP3A4
SCHEMBL30039870 0.84 ALDH1A1 (0.63) SMN1; SMN2ALDH1A1RAB9ANPC1CYP1A2
SCHEMBL20899481 0.84 ALDH1A1 (0.63) SMN1; SMN2ALDH1A1RAB9ANPC1CYP1A2
SCHEMBL19357044 0.84 SMN1; SMN2 (0.47) SMN1; SMN2ALDH1A1RAB9ANPC1CYP1A2
SCHEMBL20764179 0.83 MAPT (0.64) SMN1; SMN2ALDH1A1RAB9ANPC1CYP1A2
SCHEMBL6656001 0.83 MAPT (0.65) SMN1; SMN2ALDH1A1RAB9ANPC1DYRK1A
SCHEMBL13805532 0.81 SMN1; SMN2 (0.51) SMN1; SMN2ALDH1A1RAB9ANPC1CYP3A4
SCHEMBL13466474 0.81 RAB9A (0.63) ALDH1A1RAB9ANPC1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116635028-A Modulators of c-MYC mRNA translation and their use in the treatment of cancer 艾尼莫生物科技公司 2023-08-22 CN disclosed
CN-116262753-A Novel PIM kinase inhibitors 杭州邦顺制药有限公司 2023-06-16 CN disclosed
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2022-11-24 US disclosed
WO-2015162538-A1 HETEROCYCLIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS FOR THE TREATMENT OF HYPERPARATHYROIDISM, CHRONIC RENAL FAILURE AND CHRONIC KIDNEY DISEASE LUPIN LIMITED (IN) 2015-10-29 WO disclosed
US-20150057218-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS INC (US) 2015-02-26 US disclosed
US-20150057218-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS INC (US) 2015-02-26 US disclosed
US-8921369-B2 Inhibitors of HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2014-12-30 US disclosed
US-8921369-B2 Inhibitors of HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2014-12-30 US disclosed
US-8877707-B2 Inhibitors of HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2014-11-04 US disclosed
US-20130203656-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2013-08-08 US disclosed
US-20130203656-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2013-08-08 US disclosed
US-20130096101-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2013-04-18 US disclosed
US-20130096101-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2013-04-18 US disclosed
US-20120122864-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2012-05-17 US disclosed
US-20120122864-A1 INHIBITORS OF HCV NS5A PRESIDIO PHARMACEUTICALS, INC. (US) 2012-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220370431-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 SMN1; SMN2 3226/4885ALDH1A1 4445/4885RAB9A 2519/4885
US-20130096101-A1 INHIBITORS OF HCV NS5A HAVCR2, MAVS, EIF2AK2 SMN1; SMN2 4637/4885ALDH1A1 3636/4885RAB9A 1313/4885
US-20120122864-A1 INHIBITORS OF HCV NS5A HAVCR2, MAVS, EIF2AK2 SMN1; SMN2 4634/4885ALDH1A1 3492/4885RAB9A 1482/4885
US-20150057218-A1 INHIBITORS OF HCV NS5A HAVCR2, MAVS, EIF2AK2 SMN1; SMN2 4634/4885ALDH1A1 3492/4885RAB9A 1482/4885
US-20130203656-A1 INHIBITORS OF HCV NS5A HAVCR2, MAVS, EIF2AK2 SMN1; SMN2 4634/4885ALDH1A1 3492/4885RAB9A 1482/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.