Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 3/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PARN | O95453 | 1/20 | 0.44 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421519 | 0.93 | PNP (0.49) | PNPPDE4ABRD4HPGDPARN | |
| SCHEMBL7421933 | 0.91 | PNP (0.47) | PNPPDE4ABRD4HPGDPARN | |
| SCHEMBL7420637 | 0.85 | PGR (0.43) | PNPPDE4AHPGDKDM4ELMNA | |
| SCHEMBL7416426 | 0.84 | HPGD (0.49) | PNPPDE4ABRD4HPGDPARN | |
| SCHEMBL27501339 | 0.82 | BRD4 (0.58) | PNPBRD4HPGDPARNCNOT7 | |
| SCHEMBL7459635 | 0.79 | BRD4 (0.62) | PNPPDE4ABRD4HPGDPARN | |
| SCHEMBL3110932 | 0.79 | PDE1A (0.53) | PNPBRD4HPGDPARNCNOT7 | |
| SCHEMBL3115743 | 0.78 | ALDH1A1 (0.51) | PNPPDE4ABRD4HPGDKDM4E | |
| SCHEMBL4624547 | 0.74 | BRD4 (0.52) | PNPBRD4HPGDKDM4EPOLB | |
| SCHEMBL5078804 | 0.73 | NPC1 (0.44) | PDE4ABRD4SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257552-A1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | Aventis Pharma S.A. (FR) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001060824-A1 | XANTHINE DERIVATIVES, INTERMEDIATES AND USE FOR TREATING OSTEOPOROSIS | AVENTIS PHARMA S.A. (FR) | 2001-08-23 | — | — | WO | disclosed |