Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | PNP | P00491 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PARN | O95453 | 1/20 | 0.43 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7604062 | 0.84 | PNP (0.53) | HPGDPNPBRD4PDE4ALMNA | |
| SCHEMBL7417865 | 0.82 | YTHDC1 (0.44) | PNPKDM4EMAPK1ALDH1A1TDP1 | |
| SCHEMBL7421519 | 0.80 | PNP (0.49) | HPGDPNPBRD4PDE4AMAPK1 | |
| SCHEMBL27501339 | 0.79 | BRD4 (0.58) | HPGDPNPBRD4KDM4EPARN | |
| SCHEMBL7421933 | 0.78 | PNP (0.47) | HPGDPNPBRD4PDE4APDE4B | |
| SCHEMBL3110932 | 0.76 | PDE1A (0.53) | HPGDPNPBRD4PARNCNOT7 | |
| SCHEMBL3115743 | 0.75 | ALDH1A1 (0.51) | HPGDPNPBRD4PDE4APDE4B | |
| SCHEMBL7420637 | 0.73 | PGR (0.43) | HPGDPNPPDE4ALMNAKDM4E | |
| SCHEMBL4624547 | 0.72 | BRD4 (0.52) | HPGDPNPBRD4KDM4EPOLB | |
| SCHEMBL7423403 | 0.71 | KMT2A (0.48) | PNPPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825993-A1 | XANTHINES AND THEIR THERAPEUTIC USE | Chiroscience Limited (GB) | 1998-03-04 | — | — | EP | claimed |
| WO-1996036638-A1 | XANTHINES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |