SCHEMBL7604435

SCHEMBL7604435

COc1cc(-c2ccc(N)cn2)ccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.56
KMO O15229 1/20 0.49
KDM1A O60341 3/20 0.47
TGFBR1 P36897 1/20 0.42
ACVR1 Q04771 1/20 0.42
EGLN2 Q96KS0 1/20 0.42
FYN P06241 3/20 0.42
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40
CYP1A1 P04798 1/20 0.40
CYP1B1 Q16678 1/20 0.40
RIPK2 O43353 1/20 0.40
KIT P10721 1/20 0.40
PDGFRB P09619 1/20 0.40
PDGFRA P16234 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP3A4 P08684 1/20 0.40
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2067570 0.86 KIT (0.51) KDM1AFYNKDM4ECYP1A1CYP1B1
SCHEMBL21290163 0.83 KMO (0.50) DYRK1AKMOKDM1AEGLN2KDM4E
SCHEMBL5208478 0.80 FYN (0.55) KDM1ATGFBR1FYNGAA
SCHEMBL7604725 0.79 DYRK1A (0.56) DYRK1AKMOTGFBR1ACVR1EGLN2
SCHEMBL21084582 0.79 DYRK1A (0.63) DYRK1AKMOTGFBR1ACVR1EGLN2
SCHEMBL6176031 0.78 IDO1 (0.46) DYRK1AKMOKDM1AFYNKDM4E
SCHEMBL7684064 0.77 PSD (0.48) DYRK1AKMOPDGFRBPDGFRACYP3A4
SCHEMBL23956247 0.76 KMO (0.47) DYRK1AKMOKDM1AEGLN2FYN
SCHEMBL5210723 0.76 KDM1A (0.43) KDM1AFYNKDM4ECYP1A1CYP1B1
SCHEMBL24257876 0.76 KMO (0.71) DYRK1AKMOEGLN2CYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0920415-A1 SUBSTITUTED 2-PHENYLPYRIDINE AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 1999-06-09 EP claimed
WO-1998007700-A1 SUBSTITUTED 2-PHENYLPYRIDINE AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 1998-02-26 WO claimed
EP-1140847-B1 SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES BASF AG (DE) 2002-12-18 EP disclosed
US-6448205-B1 FOR THE DESICCATION AND/OR DEFOLIATION OF PLANTS BASF AKTIENGESELLSCHAFT (DE) 2002-09-10 US disclosed
US-6432880-B1 APPLYING TO PLANTS BASF AKTIENGESELLSCHAFT (DE) 2002-08-13 US disclosed
CN-1336918-A Substituted 2-phenylpyridines as herbicides BASF AG (DE) 2002-02-20 CN disclosed
EP-1140847-A1 SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2001-10-10 EP disclosed
WO-2000042015-A1 SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2000-07-20 WO disclosed
EP-0920415-A1 SUBSTITUTED 2-PHENYLPYRIDINE AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 1999-06-09 EP disclosed
WO-1998007700-A1 SUBSTITUTED 2-PHENYLPYRIDINE AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 1998-02-26 WO disclosed