SCHEMBL7604725

SCHEMBL7604725

COc1cc(-c2ncc(N)cc2Cl)ccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.56
RIPK2 O43353 1/20 0.48
KMO O15229 1/20 0.43
TGFBR1 P36897 1/20 0.42
ACVR1 Q04771 1/20 0.42
EGLN2 Q96KS0 1/20 0.42
ADORA1 P30542 2/20 0.40
ADORA2A P29274 1/20 0.40
PDGFRB P09619 1/20 0.40
PDGFRA P16234 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP3A4 P08684 1/20 0.40
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
KDM4E B2RXH2 1/20 0.39
FYN P06241 2/20 0.39
GAA P10253 1/20 0.39
NPC1 O15118 1/20 0.39
KDM4C Q9H3R0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7604435 0.79 DYRK1A (0.56) DYRK1ARIPK2KMOTGFBR1ACVR1
SCHEMBL6177440 0.78 ALDH1A1 (0.54) DYRK1ARIPK2ALDH1A1CYP3A4KDM4E
SCHEMBL7685207 0.77 PDGFRB (0.45) DYRK1ARIPK2KMOEGLN2PDGFRB
SCHEMBL21084582 0.75 DYRK1A (0.63) DYRK1ARIPK2KMOTGFBR1ACVR1
SCHEMBL6178667 0.75 DYRK1A (0.55) DYRK1ARIPK2KMOEGLN2PDGFRB
SCHEMBL27799366 0.75 DYRK1A (0.58) DYRK1ARIPK2KMOTGFBR1ACVR1
SCHEMBL4302847 0.74 DYRK1A (0.65) DYRK1ARIPK2KMOEGLN2PDGFRB
SCHEMBL6177330 0.72 DYRK1A (0.46) DYRK1ARIPK2KMOALDH1A1CYP3A4
SCHEMBL14413002 0.72 DYRK1A (0.51) DYRK1ARIPK2KMOEGLN2ADORA1
SCHEMBL27827494 0.72 TGFBR1 (0.58) DYRK1ATGFBR1ACVR1FYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0920415-A1 SUBSTITUTED 2-PHENYLPYRIDINE AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 1999-06-09 EP claimed
WO-1998007700-A1 SUBSTITUTED 2-PHENYLPYRIDINE AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 1998-02-26 WO claimed
EP-1140847-B1 SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES BASF AG (DE) 2002-12-18 EP disclosed
US-6448205-B1 FOR THE DESICCATION AND/OR DEFOLIATION OF PLANTS BASF AKTIENGESELLSCHAFT (DE) 2002-09-10 US disclosed
US-6432880-B1 APPLYING TO PLANTS BASF AKTIENGESELLSCHAFT (DE) 2002-08-13 US disclosed
CN-1336918-A Substituted 2-phenylpyridines as herbicides BASF AG (DE) 2002-02-20 CN disclosed
EP-1140847-A1 SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2001-10-10 EP disclosed
WO-2000042015-A1 SUBSTITUTED 2-PHENYLPYRIDINES AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2000-07-20 WO disclosed
EP-0920415-A1 SUBSTITUTED 2-PHENYLPYRIDINE AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 1999-06-09 EP disclosed
WO-1998007700-A1 SUBSTITUTED 2-PHENYLPYRIDINE AS HERBICIDE BASF AKTIENGESELLSCHAFT (DE) 1998-02-26 WO disclosed