Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7604523 | 1.00 | MGLL (0.43) | MGLLCYP4F2CYP4A11ALDH1A1GLA | |
| SCHEMBL7580544 | 0.78 | CYP4F2 (0.54) | CYP4F2CYP4A11ALDH1A1GLACYP1A2 | |
| SCHEMBL7607076 | 0.77 | CYP4F2 (0.52) | CYP4F2CYP4A11ALDH1A1GLACYP1A2 | |
| SCHEMBL7604097 | 0.77 | MGLL (0.48) | MGLLCYP2D6 | |
| SCHEMBL7604752 | 0.77 | MGLL (0.48) | MGLLCYP2D6 | |
| SCHEMBL7604094 | 0.77 | MGLL (0.48) | MGLLCYP2D6 | |
| SCHEMBL7604748 | 0.77 | MGLL (0.48) | MGLLCYP2D6 | |
| SCHEMBL14421448 | 0.74 | ALDH1A1 (0.50) | ALDH1A1GLACYP1A2CYP3A4SMN1; SMN2 | |
| SCHEMBL11868154 | 0.74 | ALDH1A1 (0.66) | ALDH1A1GLACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11023146 | 0.73 | MGLL (0.59) | MGLLCYP4F2CYP4A11ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |