Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | MAP3K9 | P80192 | 3/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | MAP3K10 | Q02779 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607098 | 0.95 | PNMT (0.38) | PNMTMAP3K9MAP3K11KDRNTRK1 | |
| Hydrochloric Acid SCHEMBL5363324 | 0.81 | PNMT (0.42) | PNMTMAP3K9MAP3K11KDRNTRK1 | |
| Hydrochloric Acid SCHEMBL9170205 | 0.81 | MAP3K9 (0.31) | PNMTMAP3K9MAP3K11 | |
| Hydrochloric Acid SCHEMBL5366069 | 0.79 | PNMT (0.42) | PNMTMAP3K9MAP3K11KDRNTRK1 | |
| Hydrochloric Acid SCHEMBL5358974 | 0.78 | PNMT (0.42) | PNMTMAP3K9MAP3K11KDRNTRK1 | |
| Hydrochloric Acid SCHEMBL7604176 | 0.77 | MAP3K9 (0.38) | PNMTMAP3K9MAP3K11KDRNTRK1 | |
| SCHEMBL8163015 | 0.77 | MAP3K9 (0.41) | PNMTMAP3K9MAP3K11KDRCA1 | |
| SCHEMBL31027164 | 0.76 | NPC1 (0.40) | PNMTMAP3K9MAP3K11KDRCA1 | |
| Hydrochloric Acid SCHEMBL5352778 | 0.76 | PNMT (0.47) | PNMTMAP3K9MAP3K11CA1CA2 | |
| SCHEMBL8857192 | 0.75 | PNMT (0.44) | PNMTMAP3K9MAP3K11KDRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524624-B1 | Use of organometallic flurorenyl compounds. | PHILLIPS PETROLEUM CO (US) | 2002-05-15 | — | — | EP | claimed |
| EP-0524624-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1993-01-27 | — | — | EP | claimed |
| EP-0524624-B1 | Use of organometallic flurorenyl compounds. | PHILLIPS PETROLEUM CO (US) | 2002-05-15 | — | — | EP | disclosed |