Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K9 | P80192 | 3/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5347494 | 0.81 | MAP3K9 (0.40) | MAP3K9MAP3K11PGRCDK1CDK2 | |
| SCHEMBL8163015 | 0.78 | MAP3K9 (0.41) | MAP3K9MAP3K11PGRKDRCA1 | |
| SCHEMBL31027164 | 0.78 | NPC1 (0.40) | MAP3K9MAP3K11PGRKDRCA1 | |
| Hydrochloric Acid SCHEMBL7604670 | 0.77 | PNMT (0.37) | MAP3K9MAP3K11PGRKDRCA1 | |
| Hydrochloric Acid SCHEMBL5359306 | 0.76 | PGR (0.41) | MAP3K9MAP3K11PGRCA1CA2 | |
| Hydrochloric Acid SCHEMBL8157425 | 0.76 | MAP3K9 (0.41) | MAP3K9MAP3K11PGRCDK1CDK2 | |
| SCHEMBL7607098 | 0.75 | PNMT (0.38) | MAP3K9MAP3K11PGRKDRCA1 | |
| Hydrochloric Acid SCHEMBL8163953 | 0.74 | MAP3K9 (0.40) | MAP3K9MAP3K11PGRCDK1CDK2 | |
| Hydrochloric Acid SCHEMBL8155675 | 0.74 | MAP3K9 (0.40) | MAP3K9MAP3K11PGRCDK1CDK2 | |
| Fluoride Ion SCHEMBL1131215 | 0.72 | PGR (0.41) | PGRCA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524624-B1 | Use of organometallic flurorenyl compounds. | PHILLIPS PETROLEUM CO (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-0524624-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |