Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 4/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | ASGR1 | P07306 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15908023 | 0.80 | CTSD (0.34) | CTSSCTSLCTSDCTSBASGR1 | |
| SCHEMBL12209106 | 0.80 | ASGR1 (0.39) | CTSSCTSLCTSDCTSBASGR1 | |
| SCHEMBL30059357 | 0.79 | CTSS (0.36) | CTSSCTSLCTSDCTSBCTSK | |
| SCHEMBL31472084 | 0.79 | CASP1 (0.32) | CTSSCTSLCTSDCTSBCTSK | |
| SCHEMBL29818922 | 0.78 | ASGR1 (0.33) | CTSSCTSLCTSDCTSBASGR1 | |
| SCHEMBL7610203 | 0.78 | ASGR1 (0.33) | CTSSCTSLCTSDCTSBASGR1 | |
| SCHEMBL23562270 | 0.77 | ASGR1 (0.32) | CTSSCTSLCTSDCTSBASGR1 | |
| SCHEMBL7608850 | 0.77 | ASGR1 (0.35) | CTSSCTSLCTSDCTSBASGR1 | |
| SCHEMBL6138236 | 0.77 | ASGR1 (0.32) | CTSSCTSLCTSDCTSBASGR1 | |
| SCHEMBL6137914 | 0.75 | DPP4 (0.31) | CTSSCTSBCTSKDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-A1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |