Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.59 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.59 |
| ▸ | ITGAL | P20701 | 2/20 | 0.59 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 7/20 | 0.40 |
| ▸ | HTR3A | P46098 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610151 | 0.86 | ITGB2 (0.74) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL7187676 | 0.83 | ITGB2 (0.80) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL8310650 | 0.83 | AR (0.60) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL6852277 | 0.81 | PDE7A (0.79) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL7189506 | 0.79 | ALDH1A1 (0.56) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL29475022 | 0.79 | HAO1 (0.55) | ICAM1CYP3A4HAO1HTR1AHTR3A | |
| SCHEMBL76793 | 0.79 | HAO1 (0.55) | ICAM1CYP3A4HAO1HTR1AHTR3A | |
| SCHEMBL16269571 | 0.79 | AR (0.51) | CYP3A4ARHAO1HTR1AHTR3A | |
| SCHEMBL20854802 | 0.77 | PDE7A (0.52) | PDE7ACYP3A4TSHRHAO1ALDH1A1 | |
| SCHEMBL15955901 | 0.76 | PKM (0.43) | PDE7ACYP3A4ARHAO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541141-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |