Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 16/20 | 0.77 |
| ▸ | MMP3 | P08254 | 14/20 | 0.77 |
| ▸ | MMP9 | P14780 | 13/20 | 0.77 |
| ▸ | MMP2 | P08253 | 11/20 | 0.77 |
| ▸ | MMP13 | P45452 | 7/20 | 0.77 |
| ▸ | MMP7 | P09237 | 3/20 | 0.77 |
| ▸ | MMP14 | P50281 | 3/20 | 0.77 |
| ▸ | MMP8 | P22894 | 6/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.36 |
| ▸ | MMP20 | O60882 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP10 | P09238 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP15 | P51511 | 1/20 | 0.36 |
| ▸ | MMP16 | P51512 | 1/20 | 0.36 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.36 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555661 | 0.92 | MMP1 (0.78) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL7604548 | 0.91 | MMP3 (0.63) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL6766456 | 0.88 | MMP1 (0.67) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL14156438 | 0.88 | MMP1 (0.67) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL12946005 | 0.87 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL4826862 | 0.87 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL2379355 | 0.87 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL645121 | 0.87 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL12247619 | 0.87 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL12247626 | 0.82 | MMP1 (0.90) | MMP1MMP3MMP9MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859784-B1 | THIO-SUBSTITUTED PEPTIDES AS INHIBITORS FOR METALLOPROTEINASES AND TNF LIBERATION | DARWIN DISCOVERY LTD (GB) | 2002-12-18 | — | — | EP | disclosed |
| US-5981490-A | ADMINISTERING A PEPTIDYL COMPOUND FOR TREATMENT IN A HUMAN OR ANIMAL OF A CONDITION ASSOCIATED WITH MATRIX METALIOPROTEINASES OR THAT IS MEDIATED BY TUMOR NECROSIS FACTOR ALPHA OR L-SELECTIN SHEDDASE | DARWIN DISCOVERY, LTD. (GB) | 1999-11-09 | — | — | US | disclosed |