Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rebimastat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 known ✓ | P03956 | 17/20 | 1.00 |
| ▸ | MMP9 known ✓ | P14780 | 13/20 | 1.00 |
| ▸ | MMP2 known ✓ | P08253 | 12/20 | 1.00 |
| ▸ | MMP13 known ✓ | P45452 | 7/20 | 1.00 |
| ▸ | MMP14 known ✓ | P50281 | 3/20 | 1.00 |
| ▸ | MMP8 known ✓ | P22894 | 6/20 | 0.59 |
| ▸ | MMP3 | P08254 | 15/20 | 1.00 |
| ▸ | MMP7 | P09237 | 4/20 | 1.00 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.45 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | MMP20 | O60882 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP10 | P09238 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP15 | P51511 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.38 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | MMP24 | Q9Y5R2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rebimastat SCHEMBL12247619 | 1.00 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL645121 | 1.00 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL4826862 | 1.00 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL12946005 | 1.00 | MMP1 (1.00) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL12247626 | 0.94 | MMP1 (0.90) | MMP1MMP3MMP9MMP2MMP13 | |
| Rebimastat SCHEMBL12247617 | 0.94 | MMP1 (0.88) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL7254495 | 0.91 | MMP9 (0.84) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL6554608 | 0.91 | MMP9 (0.84) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL12300383 | 0.91 | MMP1 (0.83) | MMP1MMP3MMP9MMP2MMP13 | |
| SCHEMBL6760102 | 0.89 | MMP3 (0.81) | MMP1MMP3MMP9MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324975-A2 | DYNAMIC RESOLUTION OF ISOMERS AND RESOLVED ISOMERS | Bristol-Myers Squibb Company (US) | 2003-07-09 | — | — | EP | claimed |
| WO-2002028809-A2 | DYNAMIC RESOLUTION OF ISOMERS AND RESOLVED ISOMERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-04-11 | — | — | WO | claimed |
| US-20110230452-A1 | Compounds and methods for the treatment of pain and other diseases | AQUILUS PHARMACEUTICALS, INC. | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230452-A1 | Compounds and methods for the treatment of pain and other diseases | MMP9, MMP10, MMP3 | MMP1 9/4885MMP9 1/4885MMP2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.