SCHEMBL7607240

SCHEMBL7607240

O=C(NC1c2ccccc2-c2ccccc21)c1cccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.61

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
APOB P04114 9/20 0.61
MTTP P55157 8/20 0.55
RXFP1 Q9HBX9 4/20 0.49
KCNK3 O14649 2/20 0.49
PPARG P37231 1/20 0.48
PPARD Q03181 1/20 0.48
NR1H4 Q96RI1 1/20 0.48
HTT P42858 1/20 0.48
PTGES O14684 1/20 0.48
KCNK9 Q9NPC2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7605815 0.86 APOB (0.63) APOBMTTPRXFP1KCNK3PPARG
SCHEMBL6799012 0.86 APOB (0.66) APOBMTTPRXFP1KCNK3PPARG
Hydrochloric Acid SCHEMBL7607266 0.85 APOB (0.65) APOBMTTPRXFP1KCNK3PPARG
SCHEMBL7607259 0.83 APOB (0.59) APOBMTTPRXFP1KCNK3PPARG
SCHEMBL7615430 0.82 APOB (0.58) APOBMTTPHTT
SCHEMBL7613563 0.82 APOB (0.59) APOBMTTPRXFP1KCNK3PPARG
SCHEMBL7605511 0.81 APOB (0.56) APOBMTTPRXFP1KCNK3HTT
SCHEMBL7607440 0.80 MTTP (0.57) APOBMTTPPPARGHTT
SCHEMBL7609278 0.80 ALDH1A1 (0.58) APOBMTTPRXFP1
SCHEMBL7612180 0.80 MTTP (0.61) APOBMTTPRXFP1KCNK3PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020032238-A1 Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032238-A1 Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments MTTP, CETP, FABP1 APOB 45/4885MTTP 1/4885RXFP1 2727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.