Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605182 | 0.92 | ALOX5 (0.58) | ALOX5KMT2AMEN1KDM4AKDM5A | |
| SCHEMBL28449798 | 0.86 | ALOX5 (0.51) | ALOX5KMT2AMEN1KDM4AKDM5A | |
| SCHEMBL14553382 | 0.76 | ALOX5 (0.79) | ALOX5KMT2AL3MBTL1KDM4AKDM5A | |
| SCHEMBL9835783 | 0.75 | ALOX5 (0.67) | ALOX5KMT2AMEN1ALDH1A1KDM4A | |
| SCHEMBL1373532 | 0.74 | CPA3 (0.56) | ALOX5KMT2AMEN1KDM4AKDM5A | |
| SCHEMBL19024897 | 0.72 | TDP1 (0.58) | ALOX5KMT2AALDH1A1 | |
| SCHEMBL14958585 | 0.72 | KMT2A (0.68) | ALOX5KMT2AMEN1L3MBTL1HTT | |
| SCHEMBL448875 | 0.71 | ALOX5 (0.77) | ALOX5KMT2AMEN1L3MBTL1HTT | |
| SCHEMBL9427262 | 0.70 | TSHR (0.46) | KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL25028176 | 0.70 | ALDH1A1 (0.53) | KMT2AMEN1L3MBTL1ALDH1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514185-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-0949922-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998013044-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING COMPULSIVE DISORDERS USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |