Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458186 | 0.77 | ADRA2A (0.47) | NISCHADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL1875671 | 0.69 | NISCH (0.63) | NISCHADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL14924864 | 0.69 | HSD17B10 (0.67) | NISCHADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL1491307 | 0.67 | HSD17B10 (0.67) | NISCHADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL7447526 | 0.66 | NISCH (0.47) | NISCHADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL2980946 | 0.65 | NISCH (0.67) | NISCHADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL11773125 | 0.65 | MCL1 (0.62) | ALOX15TSHRHSD17B10LMNATHRB | |
| Acetic Acid SCHEMBL30396484 | 0.64 | NISCH (0.58) | NISCHADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL2978779 | 0.63 | LMNA (0.63) | NISCHADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL11499063 | 0.62 | NISCH (0.57) | NISCHADRA2AADRA2BADRA2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912182-A4 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO INC (US) | 1999-12-29 | — | — | EP | disclosed |
| EP-0912182-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | Merck & Co., Inc. (US) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998000144-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO., INC. (US) | 1998-01-08 | — | — | WO | disclosed |