Sugi Predict

Sugi Predict / Compounds / SCHEMBL760829

SCHEMBL760829

SCHEMBL760829

Nc1nc(Cl)c2cc[nH]c2n1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CHUK O15111 2/20 0.51
▸ IKBKB O14920 1/20 0.51
▸ DYRK1A Q13627 1/20 0.50
▸ TTBK1 Q5TCY1 3/20 0.49
▸ TTBK2 Q6IQ55 3/20 0.49
▸ ADORA2A P29274 3/20 0.49
▸ ADORA1 P30542 3/20 0.49
▸ HRH4 Q9H3N8 2/20 0.49
▸ DHFR P00374 1/20 0.43
▸ PRKCI P41743 3/20 0.41
▸ JAK2 O60674 2/20 0.41
▸ AXL P30530 2/20 0.41
▸ DPP4 P27487 1/20 0.39
▸ CLK2 P49760 1/20 0.39
▸ AURKB Q96GD4 1/20 0.39
▸ CLK4 Q9HAZ1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31507871 1.00 CHUK (0.51) CHUKIKBKBDYRK1ATTBK1TTBK2
SCHEMBL691603 0.79 PRKCI (0.44) CHUKIKBKBDYRK1ATTBK1TTBK2
SCHEMBL1057965 0.79 HRH4 (0.51) CHUKIKBKBDYRK1ATTBK1TTBK2
SCHEMBL29700716 0.79 PRKCI (0.44) CHUKIKBKBDYRK1ATTBK1TTBK2
Hydrochloric Acid SCHEMBL28275524 0.78 HRH4 (0.50) CHUKIKBKBDYRK1ATTBK1TTBK2
SCHEMBL3391805 0.76 HRH4 (0.53) CHUKIKBKBDYRK1ATTBK1TTBK2
SCHEMBL9912500 0.76 PIK3CA (0.50) CHUKIKBKBDYRK1ATTBK1TTBK2
SCHEMBL371415 0.76 HRH4 (0.49) CHUKIKBKBDYRK1ATTBK1TTBK2
SCHEMBL2147990 0.76 PRKCI (0.41) DYRK1ATTBK1TTBK2ADORA2AADORA1
SCHEMBL13666508 0.76 PRKCI (0.41) CHUKIKBKBDYRK1ATTBK1TTBK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 350 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078119-A1 DEGRADER COMPOUNDS AND USES THEREOF BRISTOL MYERS SQUIBB CO (US) 2026-03-19 — — US disclosed
US-20260062416-A1 INHIBITORS OF KIF18A AND USES THEREOF ACCENT THERAPEUTICS INC (US) 2026-03-05 — — US disclosed
EP-4688771-A1 NOVEL FAK DEGRADER COMPOUNDS AND USES THEREOF Bristol-Myers Squibb Company (US) 2026-02-11 — — EP disclosed
US-20260028346-A1 BTK DEGRADER AND USE THEREOF ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2026-01-29 — — US disclosed
US-20260028345-A1 BTK DEGRADER AND USE THEREOF ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2026-01-29 — — US disclosed
WO-2025217212-A1 MAC1 INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-10-16 — — WO disclosed
US-20250215489-A1 Method of Sequencing L-Polynucleotide DXOME CO., LTD. (KR) 2025-07-03 — — US disclosed
US-20250134869-A1 Pyrrolo[2,3-d]pyrimidinyl, Pyrrolo[2,3-b]pyrazinyl and Pyrrolo[2,3-d]pyridinyl Acryla-mides PFIZER INC (US) 2025-05-01 — — US disclosed
WO-2025072834-A2 METHOD OF SEQUENCING AND SYNTHESIZING L-POLYNUCLEOTIDE DXOME CO., LTD. (KR) 2025-04-03 — — WO disclosed
EP-3833668-B1 PRMT5 INHIBITORS MERCK SHARP & DOHME LLC (US) 2025-03-19 — — EP disclosed
WO-1994017803-A1 ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1994-08-18 — — WO disclosed
CN-1078235-A Medicinal compound LILLY CO ELI (US) 1993-11-10 — — CN disclosed
EP-0567223-A1 Glutamic acid derivatives as antineoplastic agents ELI LILLY AND COMPANY (US) 1993-10-27 — — EP disclosed
US-5196424-A Antitumor ELI LILLY AND COMPANY (US) 1993-03-23 — — US disclosed
EP-0514540-A1 PYRROLO 2,3-d]PYRIMIDINE DERIVATIVE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL PREPARATION COMPRISING THE DERIVATIVE AS ACTIVE INGREDIENT TEIJIN LIMITED (JP) 1992-11-25 — — EP disclosed
WO-1992012718-A1 ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1992-08-06 — — WO disclosed
EP-0496617-A1 Adenosine kinase inhibitors GENSIA, INC. (US) 1992-07-29 — — EP disclosed
EP-0119591-B1 THIODEAZAPURINE DERIVATIVES Takeda Chemical Industries, Ltd. (JP) 1988-06-22 — — EP disclosed
US-4595530-A Thiodeazapurine derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-06-17 — — US disclosed
EP-0119591-A1 Thiodeazapurine derivatives Takeda Chemical Industries, Ltd. (JP) 1984-09-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028345-A1 BTK DEGRADER AND USE THEREOF BTK, SYK, TEC CHUK 391/4885IKBKB 290/4885DYRK1A 61/4885
US-20250215489-A1 Method of Sequencing L-Polynucleotide POLN, RNGTT, UNG CHUK 4551/4885IKBKB 4620/4885DYRK1A 2396/4885
US-20260078119-A1 DEGRADER COMPOUNDS AND USES THEREOF CTTN, SRC, PTK2 CHUK 2315/4885IKBKB 2608/4885DYRK1A 206/4885
US-20260028346-A1 BTK DEGRADER AND USE THEREOF BTK, SYK, LYN CHUK 360/4885IKBKB 281/4885DYRK1A 104/4885
US-20250134869-A1 Pyrrolo[2,3-d]pyrimidinyl, Pyrrolo[2,3-b]pyrazinyl and Pyrrolo[2,3-d]pyridinyl Acryla-mides JAK2, JAK3, JAK1 CHUK 271/4885IKBKB 616/4885DYRK1A 542/4885
US-20260062416-A1 INHIBITORS OF KIF18A AND USES THEREOF KIF18A, KIF18B, KIF5B CHUK 2109/4885IKBKB 1356/4885DYRK1A 2177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.