Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8057418 | 0.82 | PTGS1 (0.45) | PTGS2MAPTPTGS1KDM4ECXCR1 | |
| SCHEMBL5051189 | 0.73 | HPGDS (0.39) | MAPTKDM4ESMN1; SMN2RECQLLMNA | |
| SCHEMBL5053375 | 0.72 | HPGDS (0.43) | MAPTKDM4ESMN1; SMN2RECQLLMNA | |
| SCHEMBL5054362 | 0.72 | HPGDS (0.38) | MAPTKDM4ESMN1; SMN2RECQLLMNA | |
| SCHEMBL7605667 | 0.69 | ECE1 (0.46) | MAPTKDM4ESMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL5053021 | 0.68 | MMP2 (0.35) | MAPTKDM4ERECQLPOLBAPAF1 | |
| SCHEMBL5054264 | 0.67 | KDM4E (0.42) | MAPTKDM4ESMN1; SMN2RECQLALDH1A1 | |
| SCHEMBL29966571 | 0.67 | PTGS2 (0.42) | PTGS2MAPTKDM4ERECQLCXCL8 | |
| SCHEMBL6099297 | 0.67 | PTGS2 (0.42) | PTGS2MAPTKDM4ERECQLCXCL8 | |
| SCHEMBL15559426 | 0.67 | SMN1; SMN2 (0.47) | MAPTKDM4ESMN1; SMN2RECQLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514184-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |