Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476671 | 0.89 | KMT2A (0.47) | KMT2APTGER4HPGDPPARGPPARD | |
| SCHEMBL7612724 | 0.89 | ALDH1A1 (0.39) | KMT2APTGER4HPGDPPARGPPARD | |
| SCHEMBL8472402 | 0.88 | PTGER4 (0.49) | KMT2APTGER4MEN1POLBRAD52 | |
| SCHEMBL8473259 | 0.88 | KMT2A (0.45) | KMT2APTGER4MEN1LMNA | |
| SCHEMBL8476486 | 0.88 | PTGER4 (0.50) | KMT2APTGER4MEN1POLBRAD52 | |
| SCHEMBL7612504 | 0.87 | PTPN7 (0.39) | KMT2APTGER4PPARGPPARDPPARA | |
| SCHEMBL8472573 | 0.87 | KMT2A (0.44) | KMT2APTGER4HPGDPPARGPPARD | |
| SCHEMBL8479514 | 0.86 | PARP1 (0.38) | KMT2APTGER4PPARGPPARDPPARA | |
| SCHEMBL8474553 | 0.86 | PTGER4 (0.47) | KMT2APTGER4HPGDMEN1POLB | |
| SCHEMBL8476230 | 0.86 | PTGER4 (0.47) | KMT2APTGER4HPGDPOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741132-B1 | INDOLE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-5891902-A | OSTEOPOROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0782988-A1 | INDOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-09 | — | — | EP | disclosed |
| EP-0741132-A1 | INDOLE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-11-06 | — | — | EP | disclosed |