Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8057000 | 0.81 | HPGD (0.49) | CXCL8HPGDRAB9A | |
| SCHEMBL18607331 | 0.76 | CXCL8 (0.58) | CXCL8SRCCHRM1HPGDAKR1B1 | |
| SCHEMBL7744719 | 0.74 | CNR1 (0.45) | CXCL8CNR1CNR2HPGDNPC1 | |
| SCHEMBL31112715 | 0.74 | ESR1 (0.52) | CXCL8PPARGCHRM1PTGDR2HPGD | |
| SCHEMBL20472218 | 0.74 | CXCL8 (0.60) | CXCL8CHRM1AKR1B1FABP4FABP5 | |
| SCHEMBL7746892 | 0.72 | SMN1; SMN2 (0.45) | CXCL8CHRM1HPGDFABP4FABP5 | |
| SCHEMBL8046814 | 0.72 | CXCL8 (0.58) | CXCL8CHRM1AKR1B1FABP4FABP5 | |
| SCHEMBL8061507 | 0.71 | CXCL8 (0.50) | CXCL8CHRM1AKR1B1FABP4FABP5 | |
| Cyclohexanol SCHEMBL27805234 | 0.70 | GAA (0.51) | CXCL8HPGD | |
| SCHEMBL8046728 | 0.70 | CXCL8 (0.46) | CXCL8CHRM1AKR1B1FABP4FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514184-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |