Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.40 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7632510 | 0.78 | EPHX2 (0.50) | ALDH1A1KMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL7609798 | 0.74 | CXCL8 (0.48) | CNR1CNR2CXCL8NPC1HPGD | |
| SCHEMBL7604663 | 0.72 | SMN1; SMN2 (0.45) | CNR1CNR2CXCL8ALDH1A1KMT2A | |
| SCHEMBL8061440 | 0.72 | CXCL8 (0.58) | CXCL8PTGS2NR1H4AKR1B10UGT1A9 | |
| SCHEMBL8064167 | 0.71 | CXCL8 (0.47) | CXCL8PTGS2NR1H4AKR1B10UGT1A9 | |
| SCHEMBL8046688 | 0.70 | CXCL8 (0.49) | CXCL8ALDH1A1PTGS2NR1H4AKR1B10 | |
| SCHEMBL8057238 | 0.70 | CXCL8 (0.43) | CXCL8ALDH1A1PTGS2NR1H4AKR1B10 | |
| SCHEMBL8061466 | 0.70 | PTGS2 (0.47) | CXCL8ALDH1A1PTGS2NR1H4AKR1B10 | |
| SCHEMBL8063968 | 0.69 | CXCL8 (0.42) | CXCL8ALDH1A1KMT2ATDP1PTGS2 | |
| SCHEMBL7746864 | 0.69 | ALDH1A1 (0.44) | CXCL8ALDH1A1PTGS2NR1H4AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514160-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | claimed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | claimed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |
| US-6011021-A | GLUTAMATE-DERIVED HYDROXYPHOSPHINYL DERIVATIVE. | GUILFORD PHARMACEUTICALS INC. (US) | 2000-01-04 | — | — | US | disclosed |