Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACR | P10323 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5026552 | 0.85 | RORC (0.36) | RORCMCL1BCL2L1PSEN1PSEN2 | |
| SCHEMBL8517147 | 0.83 | ACR (0.54) | RORCKMT2AACR | |
| SCHEMBL7450471 | 0.81 | RORC (0.39) | RORCMCL1BCL2L1PSEN1PSEN2 | |
| SCHEMBL7451743 | 0.80 | RORC (0.45) | RORCMCL1BCL2L1PSEN1PSEN2 | |
| SCHEMBL7343868 | 0.79 | RORC (0.47) | RORCMCL1BCL2L1PSEN1PSEN2 | |
| SCHEMBL5174385 | 0.79 | ALDH1A1 (0.45) | RORCMCL1BCL2L1KMT2A | |
| SCHEMBL5031175 | 0.77 | SPPL2A (0.37) | MCL1BCL2L1KMT2A | |
| SCHEMBL7450627 | 0.77 | RORC (0.46) | RORCMCL1BCL2L1PSEN1PSEN2 | |
| SCHEMBL2578313 | 0.76 | MCL1 (0.50) | RORCMCL1BCL2L1PSEN1PSEN2 | |
| SCHEMBL5031155 | 0.75 | RORC (0.40) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815124-B1 | HETEROCYCLECARBONYL AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | SEARLE & CO (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1258491-A1 | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2002-11-20 | — | — | EP | disclosed |