Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.37 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7614232 | 0.87 | SMN1; SMN2 (0.41) | LMNACHRM3KMT2AESR1SMN1; SMN2 | |
| SCHEMBL7621356 | 0.84 | LMNA (0.40) | LMNACHRM3MEN1KMT2AESR1 | |
| SCHEMBL7621358 | 0.84 | LMNA (0.40) | LMNACHRM3MEN1KMT2AESR1 | |
| Bromide SCHEMBL7620571 | 0.82 | CHRNA7 (0.41) | CHRM3CHRM2CHRM1CHRNA7 | |
| Bromide SCHEMBL7660614 | 0.81 | CHRM3 (0.35) | LMNACHRM3MEN1KMT2ASMN1; SMN2 | |
| Bromide SCHEMBL7616454 | 0.81 | CHRM2 (0.42) | CHRM3MEN1KMT2ACHRM2CHRM1 | |
| Bromide SCHEMBL7617544 | 0.80 | CHRM2 (0.39) | CHRM3CHRM2CHRM1CHRNA7 | |
| Bromide SCHEMBL7618949 | 0.80 | CHRM2 (0.39) | CHRM3CHRM2CHRM1CHRNA7 | |
| Bromide SCHEMBL7622878 | 0.79 | PABPC1 (0.46) | LMNACHRM3MEN1KMT2ACHRM2 | |
| Bromide SCHEMBL11766307 | 0.76 | ALDH1A1 (0.50) | LMNAMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150673-A4 | MONO-ACYLOXY ARALKYL NEUROMUSCULAR RELAXANTS | NEWLAXANT L L C (US) | 2002-04-24 | — | — | EP | disclosed |
| EP-1150673-A1 | MONO-ACYLOXY ARALKYL NEUROMUSCULAR RELAXANTS | Newlaxant, L.L.C. (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000044377-A1 | MONO-ACYLOXY ARALKYL NEUROMUSCULAR RELAXANTS | NEWLAXANT, L.L.C. (US) | 2000-08-03 | — | — | WO | disclosed |