Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378374 | 0.81 | KMT2A (0.42) | KMT2AMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL6378830 | 0.80 | CASP6 (0.53) | LMNATSHRPOLB | |
| SCHEMBL6956090 | 0.78 | ESR1 (0.60) | ESR1KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL17287371 | 0.77 | ESR1 (0.58) | ESR1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL29556431 | 0.77 | ESR1 (0.57) | ESR1KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL11495159 | 0.77 | ESR1 (0.57) | ESR1ALDH1A1MAPTRAB9APKM | |
| SCHEMBL3647689 | 0.75 | ESR1 (0.66) | ESR1KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL27583159 | 0.75 | KMT2A (0.53) | KMT2AMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL16466482 | 0.75 | KMT2A (0.63) | ESR1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL17287403 | 0.74 | ESR1 (0.61) | ESR1KMT2AALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225895-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-1225895-A1 | FAB I INHIBITORS | SmithKline Beecham Corporation (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026654-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | disclosed |