SCHEMBL761372

SCHEMBL761372

O=C(O)c1cccc2c1c(=O)oc(=O)c1c(C(=O)O)cccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.53
GPR35 Q9HC97 2/20 0.49
NR4A1 P22736 1/20 0.48
NR4A2 P43354 1/20 0.48
NR4A3 Q92570 1/20 0.48
TYMS P04818 1/20 0.47
HSD17B10 Q99714 1/20 0.47
ALDH1A1 P00352 4/20 0.44
ALOX15 P16050 1/20 0.44
CYP1A2 P05177 1/20 0.44
HPGD P15428 2/20 0.44
GLA P06280 2/20 0.44
LMNA P02545 1/20 0.44
CDC25B P30305 1/20 0.43
KDM4E B2RXH2 2/20 0.42
GAA P10253 1/20 0.42
MAOA P21397 1/20 0.42
CA12 O43570 2/20 0.42
CA9 Q16790 2/20 0.42
PBRM1 Q86U86 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3668375 0.93 GPR35 (0.51) PARP1GPR35NR4A1NR4A2NR4A3
SCHEMBL9521993 0.89 GPR35 (0.47) PARP1GPR35NR4A1NR4A2NR4A3
SCHEMBL2804188 0.87 ALDH1A1 (0.51) PARP1GPR35NR4A1NR4A2NR4A3
SCHEMBL10683604 0.81 TTR (0.55) PARP1GPR35ALDH1A1HPGDGLA
SCHEMBL8568141 0.80 ALDH1A1 (0.46) PARP1GPR35NR4A1NR4A2NR4A3
SCHEMBL28539627 0.79 NR4A1 (0.61) PARP1GPR35NR4A1NR4A2NR4A3
SCHEMBL2876805 0.79 NR4A1 (0.61) PARP1GPR35NR4A1NR4A2NR4A3
SCHEMBL11271306 0.78 CYP1A2 (0.52) PARP1GPR35TYMSHSD17B10ALDH1A1
SCHEMBL29549589 0.77 NR4A1 (0.54) PARP1NR4A1NR4A2NR4A3TYMS
SCHEMBL126721 0.77 NR4A1 (0.54) PARP1NR4A1NR4A2NR4A3TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0629893-B1 Liquid crystal device CANON KK (JP) 1998-01-28 EP claimed
EP-0629893-A1 Liquid crystal device CANON KABUSHIKI KAISHA (JP) 1994-12-21 EP claimed
US-10577725-B2 Fiber and fiber structure TEIJIN LIMITED (JP) 2020-03-03 US disclosed
EP-2374833-B1 METHOD FOR USING CYCLIC CARBODIIMIDE TEIJIN LTD (JP) 2017-12-06 EP disclosed
US-9758496-B2 Method of using a cyclic carbodiimide TEIJIN LIMITED (JP) 2017-09-12 US disclosed
EP-2479320-B1 FIBER AND FIBER STRUCTURE TEIJIN LTD (JP) 2015-02-25 EP disclosed
US-8765862-B2 Metal nanoparticle composite and production method thereof NIPPON STEEL & SUMIKIN CHEMICAL CO., LTD. (JP) 2014-07-01 US disclosed
EP-2581368-A1 CYCLIC CARBODIIMIDE COMPOUND Teijin Limited (JP) 2013-04-17 EP disclosed
US-20130079510-A1 CYCLIC CARBODIIMIDE COMPOUND TEIJIN LIMITED (JP) 2013-03-28 US disclosed
EP-2548912-A1 METAL MICROPARTICLE COMPOSITE Nippon Steel Chemical Co., Ltd. (JP) 2013-01-23 EP disclosed
US-20130011616-A1 METAL MICROPARTICLE COMPOSITE NIPPON STEEL CHEMICAL CO., LTD. (JP) 2013-01-10 US disclosed
US-5046822-A Polyimide film; ferroelectricity CANON KABUSHIKI KAISHA (JP) 1991-09-10 US disclosed
US-4783151-A Devices utilizing pendant quinodimethane-containing polymers Hochst Celanese Corporation (US) 1988-11-08 US disclosed
US-4735492-A POLYIMIDE-ISOIDOLOQUINAZOLINEDIONE HITACHI CHEMICAL COMPANY, LTD. (JP) 1988-04-05 US disclosed
US-4719281-A Pendant quinodimethane-containing polymer HOECHST CELANESE CORPORATION (US) 1988-01-12 US disclosed
EP-0243806-A2 Pendant quinodimethane-containing polymers CELANESE CORPORATION (US) 1987-11-04 EP disclosed
EP-0219336-A2 Liquid crystal orientation controlling film and liquid crystal device using the same Hitachi Chemical Co., Ltd. (JP) 1987-04-22 EP disclosed
US-4528216-A Process for forming heat-resistant resin films of polyimide and organosilicic reactants OKI ELECTRIC INDUSTRY CO., LTD. (JP) 1985-07-09 US disclosed
US-4068923-A ELECTRO-OPTICAL CELL DAI NIPPON INSATSU KABUSHIKI KAISHA (JA) 1978-01-17 US disclosed
US-3994567-A Electro-optical cell for field effect type liquid crystal display DAI NIPPON INSATSU KABUSHIKI KAISHA (JA) 1976-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130079510-A1 CYCLIC CARBODIIMIDE COMPOUND CNOT9, CNOT1, ARPC4 PARP1 88/4885GPR35 3243/4885NR4A1 1375/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.