Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Tetraphenylphosphonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 3/20 | 0.35 |
| ▸ | CES1 | P23141 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetraphenylphosphonium SCHEMBL7616105 | 0.89 | CA2 (0.57) | CA2CA4ALDH1A1LMNAMAPT | |
| Tetraphenylphosphonium SCHEMBL1032707 | 0.87 | CA2 (0.70) | CA2CA4ALDH1A1TDP1MAPT | |
| Tetraphenylphosphonium SCHEMBL21957806 | 0.83 | CA2 (0.62) | CA2CA4CES2CES1TSHR | |
| Benzoic Acid SCHEMBL1033231 | 0.83 | CA2 (0.76) | CA2CA4ALDH1A1LMNAMAPT | |
| Tetraphenylphosphonium SCHEMBL7619517 | 0.83 | CES2 (0.39) | ALDH1A1MAPTSMN1; SMN2CES2CES1 | |
| Tetraphenylphosphonium SCHEMBL2000464 | 0.82 | CA2 (0.61) | CA2CA4ALDH1A1TDP1MAPT | |
| Benzoic Acid SCHEMBL27415178 | 0.81 | CA2 (0.81) | CA2CA4ALDH1A1MAPK1TDP1 | |
| Benzoic Acid SCHEMBL7874749 | 0.80 | CA2 (0.64) | CA2CA4ALDH1A1LMNAMAPT | |
| Benzoic Acid SCHEMBL7874595 | 0.80 | CA2 (0.64) | CA2CA4ALDH1A1LMNAMAPT | |
| Benzoic Acid SCHEMBL7871227 | 0.80 | CA2 (0.64) | CA2CA4ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020143134-A1 | Process for the neutralization of residual acid species in crude dihydric phenols | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2002-10-03 | — | — | US | disclosed |