Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899616 | 0.82 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8899562 | 0.80 | HDAC6 (0.49) | HDAC1HDAC6NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8900123 | 0.78 | ICMT (0.50) | HDAC1HDAC6NPSR1ALDH1A1 | |
| SCHEMBL5447571 | 0.78 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8898517 | 0.77 | ICMT (0.52) | ALDH1A1 | |
| SCHEMBL8900151 | 0.77 | ICMT (0.52) | ALDH1A1 | |
| SCHEMBL7615663 | 0.77 | NPY5R (0.52) | NPSR1ALDH1A1NPY5RMTORLTA4H | |
| SCHEMBL29140939 | 0.76 | HDAC1 (0.64) | HDAC1HDAC6NPSR1ALDH1A1MTOR | |
| SCHEMBL7612735 | 0.75 | L3MBTL1 (0.60) | HDAC1NPSR1 | |
| SCHEMBL7617078 | 0.75 | ALDH1A1 (0.48) | NPSR1ALDH1A1NPY5RMTORLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777471-B1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING & MFG (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-0777471-A1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-06-11 | — | — | EP | disclosed |
| US-5612377-A | OXYUREA DERIVATIVE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| WO-1996003983-A1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-02-15 | — | — | WO | disclosed |