Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7622243 | 0.95 | TSHR (0.38) | SIGMAR1TSHRCYP3A4LMNAMEN1 | |
| SCHEMBL7620405 | 0.88 | CYP3A4 (0.41) | SIGMAR1TSHRCYP3A4LMNAMEN1 | |
| SCHEMBL7614361 | 0.82 | SIGMAR1 (0.50) | SIGMAR1TSHRCYP3A4LMNAMEN1 | |
| SCHEMBL6727478 | 0.81 | SIGMAR1 (0.47) | SIGMAR1 | |
| SCHEMBL6727771 | 0.78 | SIGMAR1 (0.44) | SIGMAR1 | |
| SCHEMBL7457769 | 0.76 | SIGMAR1 (0.41) | SIGMAR1 | |
| SCHEMBL7619867 | 0.75 | ALDH1A1 (0.36) | SIGMAR1CYP3A4MEN1KMT2A | |
| SCHEMBL6717067 | 0.73 | SIGMAR1 (0.41) | SIGMAR1TSHR | |
| SCHEMBL7779720 | 0.72 | HSD17B1 (0.38) | SIGMAR1CYP3A4LMNA | |
| SCHEMBL6719207 | 0.72 | SIGMAR1 (0.49) | SIGMAR1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0517852-B1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | OREGON STATE (US) | 2002-07-10 | — | — | EP | claimed |